Nancy E. Messonnier, MD is director of the National Center for Immunization and Respiratory Diseases (NCIRD) at the Centers for Disease Control and Prevention (CDC) and leads the CDC’s efforts on COVID-19 vaccination. She joins JAMA's Q&A series to discuss the agency's response to emerging coronavirus variants, the FDA advisory hearings on the new Johnson & Johnson vaccine, and other agency activities and priorities related to COVID-19 control. Recorded February 26, 2021. Related Content: Genetic Variants of SARS-CoV-2—What Do They Mean? Coronavirus Vaccine Update From the CDC With Nancy E. Messonnier, MD SARS-CoV-2 Vaccines and the Growing Threat of Viral Variants Experts Discuss COVID-19—Vaccine Doses, Virus Variants, and More Emergence of a Novel SARS-CoV-2 Variant in Southern California SARS-CoV-2 Variants of Concern in the United States Pregnant People Getting Mixed Messages About COVID-19 Vaccines The Johnson & Johnson Vaccine for COVID-19 SARS-CoV-2 Viral Variants—Tackling a Moving Target Vaccine Distribution—Equity Left Behind? Taking Vaccine to Where the Virus Is—Equity and Effectiveness in Coronavirus Vaccinations?