24 min listen
Jeff Sperry - Safer, earlier.
ratings:
Length:
31 minutes
Released:
Jun 18, 2020
Format:
Podcast episode
Description
One minor clarification Jeff asked me to make - at around 7:15 he mentions that Vertex does not do any commercial manufacturing in-house. Vertex does not perform in-house, commercial scale production of drug substances.You will hear the following terms used during the interview. I’ve included some descriptions and links to deeper reading. Vertex - Vertex Pharmaceuticals - https://www.vrtx.com/Exotherm – An exothermic reaction is one that gives off heat. The phrase exotherm is often used as a shortened form of ‘exothermic reaction’. Unwanted exotherms in process safety cause a potential safety hazard, as they can potentially heat a reaction, beyond the safe limits of available cooling.DSC – Differential Scanning Calorimetry (DSC) is a technique for thermal analysis, in which, the difference in the amount of heat required to increased the temperature of a sample is measured as a function of temperature. It can be used to determine a number of properties of a sample.TSU – The Thermal Screening Unit (TSU) is a system used to screen materials for potential hazards associated with heating.ARC – Accelerating Rate Calorimeter (ARC) is a system used to measure heat generating characteristics of reactions, or reaction components at a range to temperatures.Other reaction data can be determined with this toolGLP Tox Lot. - A Good Laboratory Toxicology lot is a batch of a drug, or drug like material prepared during drug development with the intention of testing safety (and other) properties.API – The Active Pharmaceutical Ingredient (API) is the drug element of a medicine. The drug would be, for example, diluted down with saline solution to make a medicine ready for injection.Buller Empowerment - https://bullerempowerment.com/Taylor Howard – As Jeff mentioned, he follows Taylor on LinkedIn – she’s at https://www.linkedin.com/in/taylorhow If you want to connect with Jeff, or find out more about his lab, you can find:On LinkedIn, Jeff can be found at https://www.linkedin.com/in/jeffreybsperry/On Twitter, Jeff goes by @SafeChem79 - https://twitter.com/SafeChem79 Our theme music is "Wholesome" by Kevin MacLeod (https://incompetech.com)Music from https://filmmusic.ioLicense: CC BY (http://creativecommons.org/licenses/by/4.0/) Connect with me (Paul) at https://www.linkedin.com/in/paulorange/H.E.L. group can be found at www.helgroup.com online,on LinkedIn at https://www.linkedin.com/company/hel-group/on twitter we’re @hel_group, https://twitter.com/hel_groupor search for us on Facebook
Released:
Jun 18, 2020
Format:
Podcast episode
Titles in the series (20)
Understanding The Science Of Safety With Jensen Hughes: For episode 1 of the Modern Chemistry show, I interviewed DAMIAN STEFANCZYK, Senior Consultant at Jensen Hughes and JENS CONZEN Associate Director, Industrial and Process Safety, also of Jensen Hughes. You can find out more information about Jensen Hughes at https://www.jensenhughes.com/ Jens is on LinkedIn at https://www.linkedin.com/in/jens-conzen-15364468/ - you’ll also find links to his publications and webinars on safety through this profile. Damian is on LinkedIn at https://www.linkedin.com/in/damiandstefanczyk/ We mention a few terms in this episode that you might want to understand a bit better: -The chemical ‘MDI’, which stands for Methylenediphenyl diisocyanate. MDI is often used in the production of rigid insulation for homes and other building. In different forms, it is also used in sealants, adhesives and weather-resistant materials. If you want to jump all the way down this rabbit hole – then check out this resou by Modern Chemistry Podcast