COVID-19 pulmonary pathology in cross Atlantic pandemic epicenters

Using “ONEST” algorithm to improve reproducibility of PD-L1 assessment by pathologists: A conversation with David Rimm, the author of a recent study on Triple negative breast cancer, on using a novel statistical algorithm (ONEST) to improve reproducibility of PD-L1 assessment by pathologists. Study by Reisenbichler et al, Prospective ... by ModPath Chat

15 min listen

Composite Nuclear Grading System to Predict Survival in Epithelioid Peritoneal Mesothelioma: This episode’s guest, Dr. David Chapel, was the recipient of the 2020 USCAP Stephen Vogel Award for his research as a trainee in the University of Chicago! Here, he discusses his recent report on a multi-institutional cohort of 225 malignant peritoneal... by ModPath Chat

18 min listen

Quantitative assessment of residual pancreatic intraductal carcinoma following neoadjuvant chemotherapy: Modern Pathology Editor in Chief discusses this recent study with the author, Laura Wood MD PhD. The implications of finding that the intraductal component of pancreatic cancer is more resistant to chemotherapy are highlighted. by ModPath Chat

16 min listen

A novel tumor type with EWSR-CREB fusions blending features of Angiomatoid FH and Mesothelioma: A novel tumor type with EWSR-CREB fusions blending features of Angiomatoid FH and Mesothelioma; a discussion with the author Pedram Argani. by ModPath Chat

13 min listen

Top 20 of 2020, The Year in Review: Dr. Netto reflects on the topics of the most cited manuscripts published in Modern Pathology in 2020. A brief discussion of five selected studies involving COVID-19, DICER1, NTRK, Precursor lesions of HPV-Independent Vulvar Squamous Cell Carcinoma and ... by ModPath Chat

20 min listen

Machine Learning-Based Algorithm to Predict Death from COVID-19: Dr. Netto discusses with his two guests, Dr. Peter MCaffrey and Dr. Adam Booth, their publication on developing a machine learning model using 5 serum chemistry laboratory parameters for the prediction of death from COVID-19. by ModPath Chat

17 min listen

ALK rearranged renal cell carcinoma (ALK-RCC): The host discusses with Professor Ondrej Hes, from the Charles University in the Czech Republic, his recent multi-institutional study that further defines ALK-RCC as a genetically distinct renal cancer type showing a heterogeneous histomorphology. by ModPath Chat

15 min listen

COVID-19 pulmonary pathology in cross Atlantic pandemic epicenters: A discussion with Dr. Borczuk of New York Presbyterian Hospital- Weill Cornell Medicine on his team findings in sixty eight COVID-19 autopsies, performed early on during the pandemic, at 3 institutions in heavily hit areas (2 USA, 1 Italy). by ModPath Chat

19 min listen

APOBEC, the enemy within us!: APOBEC3B (A3B) is a newly recognized endogenous source of mutations in a range of human cancers by inflicting C-to-T or C-to-G base substitutions in 5′-TCA/T trinucleotide motifs. In this episode, Drs. Harris and Argyris discuss the impact of their rec... by ModPath Chat

18 min listen

Kinase Fusion Related Thyroid Cancers: Dr. Peter Sadow, Director of Head and Neck Pathology at MGH discusses with Modern Pathology Editor Dr. George Netto his recent work defining morphologic correlates of the expanding list of Kinase Fusions driving thyroid cancers. A triage testing algori... by ModPath Chat

16 min listen

Serous Carcinoma of The Uterine Cervix: A Vanishing Entity: The Host discusses with Dr. Philip IP (Li Ka Shing Faculty of Medicine, University of Hong Kong) his recent study re-assessing Cervical adenocarcinoma with Serous-Like morphology in light of the recent changes in the Classification of cervical adenocar... by ModPath Chat

19 min listen

Xanthogranulomatous epithelial tumor: Dr Netto discusses with Dr. Andrew Folpe a novel tumor of soft tissue and bone, provisionally termed “xanthogranulomatous epithelial tumor”. Clues to the diagnosis of this tumor type are presented. by ModPath Chat

22 min listen

Pancreatic Cancer Genetics 2020: The recent publication of the “Pan-Cancer Atlas” by the Pan-Cancer Analysis of Whole Genomes Consortium provided a great opportunity for Dr. Ralph Hruban and his team to reflect on where we stand in our understanding of the genetics of pancreatic cancer. by ModPath Chat

20 min listen

Predictors of metastases in non-seminomatous TGCT: The rationale for evolution of the pathologic staging system?: Pathological risk factors for metastatic disease in patients with testicular non-seminomatous germ cell tumors are debated. The tumor-node-metastasis (TNM) classification eighth edition for testicular cancers includes divergent versions, by the Interna... by ModPath Chat

10 min listen

Synchronous Endometrial and Ovarian Carcinomas: Clonal relationship and directionality of progression.: Dr. Britta Weigelt of MSKCC discusses her team’s study on synchronous endometrial (EC) and ovarian carcinomas (OC) in Lynch syndrome and constitutional Mismatch Repair Deficiency Syndrome (CMMRD). Contrary to sporadic synchronous ECs/OCs, which are alm... by ModPath Chat

20 min listen

A MODPATH Chat with Dr. Victor Reuter: The Digital Transformation of Anatomic Pathology: Always a visionary, Dr. Reuter was one of the earliest Anatomic Pathologists to embrace and advance the genomic and more recently the digital transformation of our field.In this episode of Meet The Expert series, Dr. Reuter shares his perspective and ... by ModPath Chat

27 min listen

Post Neo-adjuvant Chemotherapy Patterns of Residual Breast Cancer: Dr. Stuart Schnitt from Brigham and Women Hospital in Boston discusses his team'srecent findings of variable architectural and cytological patterns of residual disease in breast cancer patients with incomplete pathologic response. The relationship... by ModPath Chat

21 min listen

MHC class I loss in endometrial carcinoma: MHC class I loss by tumor cells decreases tumor neoantigen presentation to the immune system and therefore represents a possible mechanism of immunotherapeutic resistance in cancers that otherwise could be good candidates for checkpoint inhibition... by ModPath Chat

13 min listen

USCAP 2021 Long Course: "Pulmonary Pathology: Practical Problems and Solutions”. Meet the Directors!: In this special episode, Dr. Sanja Dacic and Dr. Mary Beth Beasley highlight the topics of the upcoming Long Course on Pulmonary Pathology, that will air on March 13th during the USCAP 2021 annual meeting. by ModPath Chat

16 min listen

USCAP 2021 Long Course: “Pulmonary Pathology: Practical Problems and Solutions”. HP, FHP, CTILD, UIP/IFP and more!: In this second of four special episodes highlighting the USCAP 2021 Long Course on Pulmonary Pathology, our host is joined by two distinguished faculty: Dr. Andrew Churg of the University of British Colombia and Dr. Maxwell Smith from the Mayo Clinic A... by ModPath Chat

21 min listen

Artificial intelligence for advance requesting of IHC in diagnostically uncertain prostate biopsies: Dr. Clare Verrill and Andrea Chatrian of Oxford University in England discuss their team’s study on AI for advance ordering of IHC in difficult prostate biopsy. Their elegant work shows that an AI tool making automated IHC request prior to the patholog... by ModPath Chat

20 min listen

USCAP 2021 Long Course: Biomarkers of Response to Check Point Inhibitors - beyond PD-L1: In this fourth and final episode of our special series covering this year’s USCAP Long Course on lung disease, our guest, Dr. Lynette Sholl, chief of pulmonary pathology at the Brigham and Women Hospital discusses her presentation on "Biomarkers o... by ModPath Chat

17 min listen

USCAP 2021 Long Course: Neuroendocrine Tumors of Lung, a Decade of Change!: In this third of four special episodes highlighting the USCAP 2021 Long Course on Pulmonary Pathology, our host discusses with Dr. Natasha Rekhtman of Memorial Sloan Kettering Cancer Center (MSKCC) her presentation on Neuroendocrine tumors. by ModPath Chat

22 min listen

TRIM63 as a biomarker for MiT family RCC: In this episode Dr. Rohit Mehra of University of Michigan discusses the utility of TRIM63 as a diagnostic marker to distinguish MiTF-RCC from other renal tumor subtypes with overlapping morphology. In combination with TFE3/TFEB FISH, TRIM63 RNA-ISH ass... by ModPath Chat

21 min listen

“AstroPath” Substituting cells for cosmic stars, the sky is the limit for digital and computational pathology!: In this special “Meet the Expert” episode, two distinguished guests from Johns Hopkins University discuss their pioneering approach of applying methodologies, initially developed for astronomy, to the assessment of biomarkers of tumor microenvironment ... by ModPath Chat

27 min listen

“Rebranding” Hematopathology Using Twitter: The MD Anderson Experience: In this episode, our guests, Dr. Siba El Hussein and Dr. Sanam Loghavi from the department of hematopathology at MD Anderson Cancer Ctr, discuss their experience on the role of social media in the dissemination of knowledge in hematopathology and estab... by ModPath Chat

20 min listen

A Novel Prognostic Score for NSCLC following Neoadjuvant therapy: Dr. Sabina Berezowka, from the university of Lausanne Switzerland, discusses with our host her team’s recent study describing a novel “Prognostic Score” for assessing tumor regression following Neaodjuvant therapy in non-small cell lung cancer (NSCLC).... by ModPath Chat

21 min listen

Deciphering the Molecular Underpinning of Ulcerative Colitis Associated Colorectal Cancer: Dr. Daniela Hirsch, from the Institute of Pathology at the University of Heidelberg in Germany, discusses her findings on the molecular alterations associated with colorectal cancer in the setting of Ulcerative Colitis. Using aCGH, a 48 gene p... by ModPath Chat

15 min listen

DDIT3 Immunohistochemical expression as a diagnostic marker for Myxoid Liposarcoma: Dr. Jason Hornick discusses his team recent study finding that a monoclonal antibody directed against the N-terminus of DDIT3 is a highly sensitive and specific for high-grade MLPS. DDIT3 immunostains could replace molecular genetic testing in many cas... by ModPath Chat

18 min listen

Atypical Uterine Polyps: A benign clinical course despite morphologic and molecular overlap with Adenosarcomas. by ModPath Chat

18 min listen

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COVID-19 pulmonary pathology in cross Atlantic pandemic epicenters

COVID-19 pulmonary pathology in cross Atlantic pandemic epicenters

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