19 min listen
Radio-Resistant Prostate Carcinoma: “Cribriform” morphologies and DNA Damage Response and Repair defects
FromModPath Chat
Radio-Resistant Prostate Carcinoma: “Cribriform” morphologies and DNA Damage Response and Repair defects
FromModPath Chat
ratings:
Length:
18 minutes
Released:
Oct 13, 2022
Format:
Podcast episode
Description
Locally recurrent prostate cancer from 53 patients that failed radiation therapy and underwent salvage radical prostatectomy was analyzed for clinicopathological and genomic characteristics. Most radiorecurrent tumors were enriched in cribriform morphologies (invasive cribrifom PCa and intraductal carcinoma with cribriform pattern) and demonstrated potentially targetable genomic alterations (defects in DDR genes: TP53, BRCA2, PALB2, ATR etc.). The guest, Dr. Rajal Shah of UTSW, discusses how understanding this phenotypic and genotypic diversity of radiorecurrent PCa is critically important for future management of such patients. Hosted on Acast. See acast.com/privacy for more information.
Released:
Oct 13, 2022
Format:
Podcast episode
Titles in the series (58)
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