Welcome back, friends! I’m Brian Sanders and this is the Peak Human podcast. I’m also the owner of NoseToTail.org where you can get all kinds of properly raised meats and the creator of the Food Lies film. We continue to work on the film daily and are just as desperate to finish it and get out to the world as you are. I know it’s taking longer than expected, but we are making something truly special and there are a lot of factors we’re dealing with. It will be worth it, trust me. This episode today is very special and a long time in the making. I got the top 2 audience favorites on one podcast. This nutrition stuff is so complex, it’s never enough to get one side of the story so I thought I could at least get 2. I try to stay out of giving my opinions in this one. Perhaps 3 would be a crowd. We talk about so many interesting topics such as the carbohydrate-insulin model of obesity, the alternatives to this. The personal fat threshold, the insulin model of disease which is separate from how one becomes overweight. Satiety and how it fits into this. The processing of foods and how it plays in. Basal insulin vs. bolus. THe satiety vs. calorie theory.  Also the big PUFA debate - are they as bad as they’re made out to be? I think they are, but these 2 don’t seem to think there’s anything uniquely problematic with them other than they supply empty calories and we eat way too much of them. So they do think you should cut them out. I try to not interject much. I’m not trying to insert myself too much into these discussions. I have all kinds of guests on with differing opinions to expose people to all the angles of this complex nutrition world. I think something particularly with these guys and PUFAs, especially omega 6, is that they haven’t spent the time to really dig into these details enough. They have busy lives and are focused on other areas of health. Just an idea. Really we’re looking at the mystery of what goes on with food we eat and it's role in disease and/or obesity (which are independent of each other). Everyone should be interested in this to some extent. Maybe not to the level of a 90 minute podcast into some of the small details, but these are important questions that need to be answered.  Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading major medical center in Seattle. His research and medical practice are focused on the practical implementation of diet and exercise for health optimization. He has an undergraduate degree in mechanical engineering and utilizes engineering principles when dealing with complex systems such as human health and nutrition. Dr. Ben Bikman is a researcher and professor specializing in metabolic function, insulin resistance, and the drivers of metabolic disorders. He has a PhD in bioenergetics, he did a postdoctoral fellowship with the Duke National University of Singapore in metabolic disorders, and he’s currently exploring the contrasting roles of insulin and ketones as key drivers of metabolic function.   GET THE MEAT! http://NosetoTail.org GET THE FREE SAPIEN FOOD GUIDE! http://Sapien.org   SHOW NOTES [1:00] The 4 steps of insulin resistance.  [3:00] A deep dive into how insulin resistance spreads throughout the body.  [8:00] Hypertrophy and Hyperplasia of fat cells. [14:00] Carbohydrate insulin model. [27:00] How refined food plays a role in obesity. [31:45] How processing, cooking, and pulverizing our food can lead to different hormonal reactions. [42:20] Differences between basal and postprandial insulin.  [46:00] Obesity is a function of insulin and excessive energy intake  [56:00] Are PUFAs truly as bad as they are portrayed to be? Soybean Oil Is More Obesogenic and Diabetogenic than Coconut Oil and Fructose in Mouse: Potential Role for the Liver [1:09:40] How refined fats and carbs affect satiation and brain chemistry. [1:18:20] A recap and discussing Brian’s Uganda trip.   GET THE MEAT! http://NosetoTail.org GET THE FREE