Dr. Carmine Pariante is a Psychiatrist who studies Treatment Resistant Depression. He is working towards a more specific definition of what constitutes a resistance to treatment interventions, and how to use that information in increasing efficacy in treatment.  Sofia Quaglia is a medical journalist who wrote a piece on Dr. Pariante's work, and joins today to help describe this work, and discuss her goals of highlighting the need for definition in diagnosis and treatment of mental health disorders.  You can view the video of this interview by becoming a Patron of the show at www.patreon.com/breakabrain.