This episode I discuss the science of gratitude, which has been shown in peer-reviewed studies to have tremendous positive effects on mental and physical health. I explain, however, that most commonly used gratitude practices are ineffective (such as gratitude lists). The key elements of highly effective gratitude practices are described including the essential need for story (narrative), receiving or perceiving gratitude, rather than giving it, and the role that theory of mind plays in this context. I also discuss why we can't simply make up feelings of gratitude and how reluctance undermines the process. I also explain the neural circuit mechanisms that underlie the reductions in fear and increases in motivation and lowering of inflammatory chemicals that effective narrative-based gratitude can trigger. Throughout the episode I use the science of gratitude to design a brief but highly effective protocol.   Thank you to our sponsors: ROKA - https://www.roka.com - code "huberman" InsideTracker - https://www.insidetracker.com/huberman  Magic Spoon - https://www.magicspoon.com/huberman    Our Patreon page: https://www.patreon.com/andrewhuberman    Supplements from Thorne: http://www.thorne.com/u/huberman    Social: Instagram - https://www.instagram.com/hubermanlab  Twitter - https://twitter.com/hubermanlab  Facebook - https://www.facebook.com/hubermanlab  Website - https://hubermanlab.com  Newsletter - https://hubermanlab.com/neural-network    Links: Neural Correlates of Gratitude (Damasio) - doi: 10.3389/fpsyg.2015.01491  Reducing Inflammatory Cytokines & Fear With Gratitude - https://doi.org/10.1016/j.bbi.2021.04.019      Timestamps: 00:00:00 Introduction: Gratitude Science & Surprises 00:01:50 Controlling Heart Rate with Story 00:04:33 Sponsors: ROKA, InsideTracker, Magic Spoon 00:09:11 Major, Long-Lasting Benefits of Gratitude Practice 00:12:20 Prosocial vs. Defensive Thinking, Behaviors, & Neural Circuits  00:17:50 Why We All Need an Effective Gratitude Practice 00:21:22 Neurochemistry & Neural Circuits of Gratitude 00:25:10 Prefrontal Cortex Set Context 00:30:10 Ineffective Gratitude Practices; Autonomic Variables 00:34:55 Key Features of Effective Gratitude Practices: Receiving Thanks & Story 00:42:30 Theory of Mind Is Key 00:45:50 Building Effective Gratitude Practices: Adopting Narratives, Duration 00:52:28 Narratives That Shift Brain-Body Circuits  00:56:15 You Can’t Lie About Liking Something; Reluctance In Giving 00:59:55 How Gratitude Changes Your Brain: Reduces Anxiety, Increases Motivation 01:03:00 5 Minutes (Is More Than Enough), 3X Weekly, Timing Each Day  01:05:44 Empathy & Anterior Cingulate Cortex 01:07:35 Reducing Inflammation & Fear with Gratitude 01:10:56 Serotonin, Kanna/Zembrin  01:16:00 Neuroplasticity, Pharmacology, Brain Machine Interfaces 01:18:50 The Best Gratitude Practices: & How To, My Protocol 01:24:25 Subscribe & Feedback, Supporting Sponsors, Supplements (Thorne)   Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.   Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com