Top 300 Drugs Pocket Reference Guide (2021 Edition)
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About this ebook
The "Top 300 Drugs Pocket Reference Guide" serves as a portable reference to learn the essential information for the most commonly prescribed drugs. This on-the-go resource details the brand name, pharmacologic class, mechanism of action, dosage form, common use, and other clinical details for each drug. Whether you’re a pharmacy student or healthcare professional, this guide will serve as an effective resource to learn the basic characteristics of the most popular drugs.
Drug details include:
• Brand Names
• Pharmacologic Classes
• Mechanisms of Action
• Common Uses
• Dosage Forms
• Dosing Information
• Administration Methods
• Monitoring Guidelines
• Contraindications
• Drug Interactions
• Adverse Effects
• Black Box Warnings
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Top 300 Drugs Pocket Reference Guide (2021 Edition) - Coventry House Publishing
ACYCLOVIR
Brand Names
• Zovirax, Sitavig, Avaclyr
Pharmacologic Class
• Antiviral
Mechanism of Action
• Acyclovir is converted to the active triphosphate form, which interferes with viral DNA polymerase and inhibits viral DNA replication.
Dosage Forms
• Oral (tablet, buccal tablet, capsule, suspension), topical (ointment, cream), intravenous (solution)
Common Uses
• Treatment of genital herpes, herpes zoster (shingles), and varicella zoster (chickenpox)
Quick Facts
• Reduce dosage in renal impairment (CrCl < 25 mL/min/1.73 m²).
• Infuse IV form over at least 1 hour and avoid IV push, IM, or SubQ injection.
• Wear rubber gloves when applying ointment or cream to prevent virus transmission to other parts of the body.
• Drink plenty of fluids when using oral form to prevent renal toxicity.
• Side effects: diarrhea, nausea, vomiting, headache
Back to drug list.
ADALIMUMAB
Brand Name
• Humira
Pharmacologic Class
• TNFα inhibitor
Mechanism of Action
• Binds to TNFα and prevents its interaction with cell surface TNF receptors, thereby inhibiting cytokine-driven inflammatory processes.
Dosage Form
• Subcutaneous (solution)
Common Uses
• Treatment of rheumatoid arthritis, psoriatic arthritis, Chron’s disease, and ulcerative colitis
Quick Facts
• Black Box Warning – Patients are at an increased risk of serious infections leading to hospitalization or death, including tuberculosis (TB), bacterial sepsis, invasive fungal infections, and infections due to other opportunistic pathogens. Lymphoma and other malignancies have been reported.
• Avoid live vaccines during therapy.
• All patients should be screened for TB before and during therapy.
• Side effects: injection site pain or reaction, rash, headache, upper respiratory tract infection, sinusitis
Back to drug list.
ALBUTEROL
Brand Names
• ProAir, Ventolin, Proventil
Pharmacologic Class
• Beta2-agonist
Mechanism of Action
• Relaxes bronchial smooth muscle by binding to beta2-adrenergic receptors.
Dosage Forms
• Inhalation (powder, solution, suspension), oral (tablet, syrup)
Common Uses
• Treatment of asthma, exercise-induced asthma, COPD, and bronchospasm
Quick Facts
• HFA inhalers should be shaken well before each use. Prime prior to first use and when inhaler has not been used for more than 2 weeks by spraying into air 3 to 4 times.
• Mouthpiece of HFA inhalers should be cleaned at least once per week by removing the canister and running under warm water, then air-drying completely.
• Side effects: palpitations, tremors, dizziness, cough, nervousness
Back to drug list.
ALBUTEROL-IPRATROPIUM
Brand Names
• Combivent Respimat, DuoNeb
Pharmacologic Class
• Combination beta2-agonist and anticholinergic
Mechanism of Action
• Albuterol relaxes bronchial smooth muscle by binding to beta2-adrenergic receptors, and ipratropium blocks the action of acetylcholine at parasympathetic sites in bronchial smooth muscle causing bronchodilation.
Dosage Forms
• Inhalation (solution, aerosol powder, spray)
Common Use
• Treatment of COPD
Quick Facts
• Avoid spraying in or near eyes as this may cause eye pain, temporary blurring of vision, visual halos, mydriasis, or new onset or worsening of narrow-angle glaucoma.
• Use with caution in patients with narrow-angle glaucoma, BPH, or bladder neck obstruction.
• Soft-mist inhaler should be primed prior to first use or if not used in more than 21 days.
• Clean mouthpiece of soft-mist inhaler at least once per week with a damp cloth or tissue.
• Side effects: dry mouth, upper respiratory tract infection, sinusitis
Back to drug list.
ALENDRONATE
Brand Names
• Fosamax, Binosto
Pharmacologic Class
• Bisphosphonate
Mechanism of Action
• Inhibits osteoclast-mediated bone resorption.
Dosage Forms
• Oral (tablet, effervescent tablet, solution)
Common Uses
• Treatment and prevention of osteoporosis; treatment of Paget’s disease
Quick Facts
• Medication should be taken in the morning at least 30 minutes before the first food, beverage, and other medications of the day. Patient should stay upright for at least 30 minutes and until after eating to prevent esophageal irritation.
• Oral tablet should be taken with 6 to 8 oz. of plain water, and oral solution should be followed with at least 2 oz. of plain water.
• Side effects: abdominal pain, acid regurgitation, constipation, diarrhea, and esophagitis
• Less common side effects: osteonecrosis of the jaw, atypical femur fracture
Back to drug list.
ALLOPURINOL
Brand Names
• Zyloprim, Aloprim
Pharmacologic Class
• Xanthine oxidase inhibitor
Mechanism of Action
• Decreases the production of uric acid by inhibiting the action of xanthine oxidase.
Dosage Forms
• Oral (tablet), intravenous (powder for solution)
Common Uses
• Treatment of gout; prevention of tumor lysis syndrome and recurrent nephrolithiasis
Quick Facts
• Reduce dosage in renal impairment (CrCl < 20 mL/min).
• Take medication after meals to reduce gastric irritation.
• Patients should be counseled to immediately report a skin rash as it can develop into Stevens-Johnson syndrome or toxic epidermal necrolysis.
• Medication may take several weeks to have an effect.
• Side effects: diarrhea, nausea, precipitation of acute gout attacks
Back to drug list.
ALPRAZOLAM
Brand Name
• Xanax
Pharmacologic Class
• Benzodiazepine
Mechanism of Action
• Causes CNS depression by potentiating the effects of GABA (an inhibitory neurotransmitter).
Dosage Forms
• Oral (tablet, disintegrating tablet, solution)
Common Uses
• Treatment of anxiety disorders and panic disorder
Quick Facts
• DEA Schedule IV
• Black Box Warning – Concomitant use with opioids increases risk of sedation, respiratory depression, coma, or death.
• Avoid abrupt discontinuation to prevent withdrawal symptoms.
• Avoid alcohol, grapefruit, and grapefruit juice.
• Dose adjustment recommended in advanced liver disease.
• Side effects: drowsiness, dizziness, ataxia, lightheadedness
Back to drug list.
AMIODARONE
Brand Names
• Cordarone, Pacerone
Pharmacologic Class
• Antiarrhythmic (Class III)
Mechanism of Action
• Primarily blocks potassium channels, increasing the duration of the action potential and refractory period in myocardial tissue. Also interferes with the functioning of beta-adrenergic receptors, sodium channels, and calcium channels.
Dosage Forms
• Oral (tablet), intravenous (solution)
Common Uses
• Treatment and prevention of ventricular arrhythmia
Quick Facts
• Black Box Warning – Risk of pulmonary toxicity, hepatotoxicity, and worsened arrhythmia. Treatment should be initiated in a clinical setting.
• Monitor pulmonary function, thyroid function, and liver function. Perform baseline and regular ophthalmic exams.
• Avoid St. John’s wort and grapefruit juice.
• Side effects: hypotension, heart block, pulmonary fibrosis, sinus bradycardia, skin discoloration, hypothyroidism, hyperthyroidism, corneal deposits, optic neuropathy
Back to drug list.
AMITRIPTYLINE
Brand Name
• Elavil
Pharmacologic Class
• Tricyclic antidepressant
Mechanism of Action
• Increases the synaptic concentration of serotonin and norepinephrine in the CNS by inhibiting their reuptake at presynaptic nerve terminals.
Dosage Form
• Oral (tablet)
Common Uses
• Treatment of depression and neuropathic pain; migraine prevention
Quick Facts
• Black Box Warning – Increased risk of suicidal thoughts and behavior, especially in children, adolescents, and young adults.
• Can prolong the QT interval.
• Do not abruptly discontinue medication.
• Symptomatic improvement may take several weeks.
• Use is contraindicated during or within 14 days of MAOI administration.
• Side effects: dry mouth, blurred vision, urinary retention, constipation, weight gain, drowsiness
Back to drug list.
AMLODIPINE
Brand Names
• Norvasc, Katerzia
Pharmacologic Class
• Calcium channel blocker
Mechanism of Action
• Dihydropyridine CCB that blocks the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle which results in increased peripheral arterial vasodilation and decreased peripheral vascular resistance.
Dosage Forms
• Oral (tablet, suspension)
Common Uses
• Treatment of chronic stable angina and variant angina, hypertension
Quick Facts
• May worsen angina and increase the risk of MI after starting or increasing dose.
• Risk of peripheral edema can be minimized if medication is administered at bedtime and lower doses are used (2.5 or 5 mg/day).
• Side effects: peripheral edema, fatigue, reflex tachycardia, headache, flushing
Back to drug list.
AMLODIPINE-BENAZEPRIL
Brand Name
• Lotrel
Pharmacologic Class
• Combination calcium channel blocker and ACE inhibitor
Mechanism of Action
• Amlodipine is a dihydropyridine CCB that blocks the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle which results in increased peripheral arterial vasodilation and decreased peripheral vascular resistance. Benazepril inhibits the angiotensin converting enzyme (ACE), which prevents the conversion of angiotensin I to angiotensin II, a
potent vasoconstrictor.
Dosage Form
• Oral (capsule)
Common Use
• Treatment of hypertension
Quick Facts
• Black Box Warning – Discontinue use as soon as possible if pregnancy is detected.
• Contraindicated in patients with history of angioedema, concomitant use with aliskiren in diabetic patients, concomitant use with neprilysin inhibitor, or within 36 hours of switching to or from a neprilysin inhibitor.
• Use caution in patients with impaired renal function.
• Patients should avoid potassium supplements or salt substitutes containing potassium without first consulting healthcare provider.
• Side effects: cough, headache, edema, angioedema
Back to drug list.
AMOXICILLIN
Brand Names
• Amoxil, Trimox, Moxatag
Pharmacologic Class
• Penicillin antibiotic
Mechanism of Action
• Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins, which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls.
Dosage Forms
• Oral (tablet, capsule, powder for suspension, chewable tablet)
Common Uses
• Treatment of ear, nose, and throat infections (pharyngitis/tonsillitis, otitis media), genitourinary tract infections, H. pylori eradication, lower respiratory tract infections, skin and soft tissue infections, and sinusitis
Quick Facts
• Keep suspension refrigerated and discard after 14 days.
• Take at even intervals, preferably around the clock.
• Side effects: diarrhea, nausea, vomiting, rash
Back to drug list.
AMOXICILLIN-CLAVULANATE
Brand Name
• Augmentin
Pharmacologic Class
• Penicillin antibiotic
Mechanism of Action
• Amoxicillin inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins, which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Clavulanate inactivates beta-lactamase enzymes, which protects amoxicillin from degradation and increases its spectrum of activity.
Dosage Forms
• Oral (tablet, powder for suspension, chewable tablet)
Common Uses
• Treatment of acute otitis media, community-acquired pneumonia, sinusitis, skin and skin structure infections, and UTIs
Quick Facts
• Keep suspension refrigerated and discard after 10 days.
• Take at the start of a meal to increase absorption and decrease GI upset.
• Side effects: diarrhea, nausea, vomiting, rash
Back to drug list.
AMPHETAMINE-DEXTROAMPHETAMINE
Brand Names
• Adderall, Mydayis
Pharmacologic Class
• CNS stimulant
Mechanism of Action
• Blocks the reuptake of norepinephrine and dopamine in presynaptic nerve endings and increases their release into the extraneuronal space.
Dosage Forms
• Oral (tablet, capsule)
Common Uses
• Treatment of ADHD and narcolepsy
Quick Facts
• DEA Schedule II
• Black Box Warning – High potential for abuse, and administration for prolonged periods of time may lead to dependence. Misuse may cause sudden death and serious cardiovascular adverse reactions.
• Use is contraindicated during or within 14 days of MAOI administration, including linezolid or methylene blue.
• Gradually increase dosing and avoid abrupt discontinuation to prevent withdrawal symptoms.
• Use with caution in patients with a history of seizures.
• Side effects: loss of appetite, weight loss, restlessness, nervousness, nausea, diarrhea
Back to drug list.
ANASTROZOLE
Brand Name
• Arimidex
Pharmacologic Class
• Aromatase inhibitor
Mechanism of Action
• Non-steroidal aromatase inhibitor that blocks the conversion of androgens to estrogens in peripheral tissues.
Dosage Form
• Oral (tablet)
Common Use
• Treatment of breast cancer in postmenopausal women
Quick Facts
• Can decrease bone mineral density. (Monitor at baseline and every 1 to 2 years with DEXA scan.)
• Consider monitoring total cholesterol and LDL during therapy.
• Use is not recommended in premenopausal women.
• Side effects: hot flashes, fatigue, nausea, vomiting, rash
Back to drug list.
APIXABAN
Brand Name
• Eliquis
Pharmacologic Class
• Factor Xa inhibitor
Mechanism of Action
• Reversible and selective active site inhibitor of free and clot-bound factor Xa, resulting in decreased thrombin generation and thrombus formation.
Dosage Form
• Oral (tablet)
Common Uses
• Treatment and prophylaxis of DVT or PE; used to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (AF); prophylaxis of DVT in patients who have undergone hip or knee replacement surgery
Quick Facts
• Black Box Warnings – Premature discontinuation increases the risk of thrombotic events. To reduce risk consider coverage with another anticoagulant if apixaban is discontinued for a reason other than pathological bleeding or completion of therapy. Patients undergoing neuroaxial anesthesia or spinal puncture have an increased risk of epidural or spinal hematomas which could result in permanent paralysis.
• Dosage adjustment required in patients with renal
impairment and nonvalvular atrial fibrillation (2.5 mg twice daily in patients with at least two of the following characteristics: age ≥ 80 years, body weight ≤ 60 kg, or serum creatinine ≥ 1.5 mg/dL).
• Side effects: hemorrhage, bruising, syncope, anemia
Back to drug list.
ARIPIPRAZOLE
Brand Name
• Abilify
Pharmacologic Class
• Antipsychotic
Mechanism of Action
• May exert its effects through partial agonist activity at the dopamine D2 and serotonin 5-HT1A receptors, and antagonist activity at serotonin 5-HT2A receptors.
Dosage Forms
• Oral (tablet, disintegrating tablet, solution), intramuscular (powder for suspension)
Common Uses
• Treatment of bipolar disorder, schizophrenia, major depressive disorder, Tourette’s syndrome, and irritability associated with autistic