Mandelic Acid: Aha
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About this ebook
Madhuri Sharon
Dr. Madhuri Sharon is an eminent scientist has already written 4 books. PRESENT POSITIONS Executive Director, nsnRc for Nanotechnology & Bionanotechnology Managing Director, Monad Nanotech Adjunct Professor University of Mumbai Professor Emeritus JJTU Consultant for Nanotechnology U.N.O. (Asia-Pacific Region) EDUCATIONAL B.Sc. (Hons.) Bhagalpur University 1962 M.Sc. Patna University 1964 Ph.D. Leicester University 1969 (Merit Scholarship UK) Post-Doc Bolton Institute of Technology, UK 1969 - 71 SPECIALIZATIONS Nano-Biotechnology Plant Biotechnology Plant Tissue Culture Plant Growth Regulators PUBLICATIONS Research Papers 144 Books 4 PATENTS TOTAL 11 POSITIONS Held Research Assistant LEICESTER UNIVERSITY 1966-1968 Post Doc-Fellow BOLTON INSTITUTE OF TECHNOLOGY 1968 -1972 Pool-Officer CSIR POOL OFFICER 1972 - 1975. Post-Grad Lecturer POONA UNIVERSITY 1975 - 1983 Scientist HINDUSTAN LEVERS LTD 1979 - 1980 In-Charge of Radio Isotope ICRISAT 1984 - 1985 Visiting Scientist GHENT UNIVERSITY, BELGIUM 1988 Manager & Head EXCEL IND LTD & C.C.S.RI 1989 -1999 Vice President GUFIC Biosciences 1999 2000 Director RELIANCE IND. LTD 2001 2003 Adjunct Professor UNIVERSITY OF MUMBAI 2004 2009 Principal SICES COLLEGE, AMBERNATH 2009 2011 PROFESSIONAL POSITIONS Held Technical Director Shaili Polymers Pvt. Ltd. .Ahmedabad Technical Director INDAGRO Tissue Tech Pvt Ltd.Bombay Technical Director Aero Auto Ltd. Goregaon, Bombay Director Garden Biotechnica (P) Ltd., Kadav, Senior Consultant Biotech Consortium, New Delhi HONORARY POSITIONS/ MEMBERSHIPS Treasurer Assoc. of Plant Physiologists of SAARC countries Executive member The Orchid Soc of India Editor Journal of Agro-technology & Bio-energy Member International Plant Tissue Culture Association Member American Society of Horticultural Sciences Life Member Indian Women Scientists Association Member Indian Science Congress Life Member Indian Society of Plant Physiologists Member Plant Growth Regulator Society of India Life Member Indian Society of Agro-technology & Bio-energy. Member International In Vitro Society. Jt. Secretary Carbon Society of India (Maharashtra Chapter) EDITORIAL ADVISORY BOARD 1. AGROBIOS RESEARCH 2. JOURNAL OF AGROTECHNOLOGY & BIOENERGY GUIDED Ph. D. Students 16 STUDENTS DOING Ph. D UNDER ME 5 M.Tech, B.Tech &M. Sc. (DESERTATION) 85 Ph. D GUIDE of (1)Mumbai University (2)North-Maharashtra University Jalgaon (3) Assam University, Silchur, Assam (4) Bhagalpur University, Bihar (5) Solapur Univ, Soplapur RESEARCH COLLABORATIONS 1. North Carolina State University, USA 2. Virginia Commonwealth University, USA 3. Wayne State University, USA 4. Oklahoma University, USA 5. Chubu University Japan 6. Nagoya Institute of Technology, Japan AWARDS Vijay Shree - 1997. Lok Vigyan Sanman of Bundelkhand - 2003 Indian Leadership Award for Industrial Development - 2011 Rashtra Pratibha Puraskar - 2012. VISITING SCIENTIST - Nagoya University, Japan 1996 and 2004 COUNTRIES VISITED For giving lectures, scientific survey, research collaboration, conferences & for Industrial, commercial and buy back collaboration work, Belgium, Canada Denmark, France, Germany, Israel, Japan, Korea, Luxembourg, Nepal, Netherlands, Poland, Singapore, Spain, Sweden, Switzerland, Thailand, UK, USA, U.S.S.R. SPECIAL ASSIGNMENTS To assess & do the Case Studies on the Development and Commercialization of Nanotechnology-based Value Added Products from the Asia-Pacific region for UNITED NATIONS To write report on status of Fuel Cell in India and its road map till 2022 for MNRE Assessment of Status of Floriculture in SAARC countries for Biotech Consortium India Ltd. (a cell of DBT)
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Mandelic Acid - Madhuri Sharon
Copyright © 2018 by Sharon, Durve, Pandey, Pathak.
ISBN: Softcover 978-1-4828-1671-6
eBook 978-1-4828-1672-3
All rights reserved. No part of this book may be used or reproduced by any means, graphic, electronic, or mechanical, including photocopying, recording, taping or by any information storage retrieval system without the written permission of the author except in the case of brief quotations embodied in critical articles and reviews.
Dr. Madhuri Sharon, is Executive Director of N.S,N, Research Centre for Nanotechnology & Bionanotechnology, she is also Managing Director of MONAD Nanotech Pvt Ltd. She has many patents and publications including four books to her credit.
Because of the dynamic nature of the Internet, any web addresses or links contained in this book may have changed since publication and may no longer be valid. The views expressed in this work are solely those of the author and do not necessarily reflect the views of the publisher, and the publisher hereby disclaims any responsibility for them.
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CONTENTS
Preface
Chapter 1 Mandelic Acid: Physics and Chemistry
1.1 Introduction
1.2 Structure of Mandelic acid
1.3 Properties of Mandelic cid
1.4 Conclusion
Chapter 2 Mandelic acid: Economic Importance
2.1 Introduction: An acid that heals
2.2 For Skin Care
2.3 Mandelic acid as an anti-microbial and anti-septic agent
2.4 Vaginal contraceptive:
2.5 Other Uses of Mandelic acid
2.6 The disadvantages of using Mandelic acid in health care.
2.7 Conclusion
Chapter 3 Mandelic Acid: Chemical Synthesis
3.1 Introduction
3.2 Production of Mandelic Acid from Amygdalin
3.3 Production of Mandelic Acid from Benzaldehyde
3.4 Derivatives of Mandelic acid
3.5 Drawbacks of chemical synthesis of Mandelic acid
3.6 Conclusions
Chapter 4 Enzymes and Biotransformations
4.1 Introduction
4.2 Bioconversion and Biotransformation
4.3 Enzymes
4.4 Conclusion
Chapter 5 Nitrilases
5.1 Introduction to Nitrilase
5.2 Structure of Nitrilase
5.3 Physico-Chemical Properties of Nitrilase
5.4 The Nitrilase Super-family
5.5 Cyanide Degrading Nitrilases
5.6 Nitrile Hydratase and Amidase
5.7 Detecting the presence of Nitrilase
5.8 Occurrence of Nitrilases
5.9 Nitrilase Catalyzed Reactions in Living Systems
5.10 Nitrilase catalyzed conversion of Mandelonitrile to Mandelic acid
5.11 Preservation and Stabilization of Immobilized or Unimmobilized Microbial cells having Nitrilase Activity
5.12 Evolutionary Analysis of Nitrilases
5.13 Industrial applications of Nitrilase
5.14 Conclusion
Chapter 6 Mandelic Acid: Chemical analysis
6.1 Introduction
6.2 Paper Chromatography
6.3 Thin layer chromatography
6.4 High-performance liquid chromatography
6.5 Gas Chromatography
6.6 Mass Spectrometry
6.7 Nuclear Magnetic Resonance Spectroscopy
6.8 Conclusion
Chapter 7 Bioconversion of Mandelonitrile to Mandelic acid
7.1 Introduction
7.2 Nitrilase Catalyzed Conversion of Mandelonitrile to Mandelic acid by Microbes
7.3 Nitrilase Catalyzed Conversion of Mandelonitrile to Mandelic acid by Fungi
7.4 Nitrilase Catalyzed Conversion of Mandelonitrile to Mandelic acid by Plants
7.5 Conclusion
References
PREFACE
In olden days, distances between townships, limited funds, the lack of available medical professionals and services all indicated that a girl be not only a wife, mother, and housekeeper, but doctor as well. Folklore healing practices, curative use of herbs, and different medicinal family secrets
were stealthily guarded and handed down from one generation to the next. Some of the cures were really valuable and effective whereas some of the grandmother’s practices were not actually cures at all, and were just some superstitions and delusion cures which had no practical applications e.g. practice of hanging herbs around a child’s neck to assist him lower teeth. Through the years, the superstitions were left behind to start the era of herbal treatment, resulting into birth of Ayurveda in India, Yunani medicine in Middle East and Chinese Herbal treatment and later witch doctors in Europe.
It was while living in tune with nature and studying wildlife that early man learned of the medicinal powers
of herbs. Animals bitten by a toxic snake survived after chewing snakeroot, a wounded bear rolled in mud to higher heal and escape infection, and old, rheumatoid deer eased their distress and made joints more limber by resting under the therapeutic rays of the sun. In days of old, there was no other solution to treat illness and discomfort, assist heal wounds, or treatment bodily dysfunctions than with pure means.
Although there is no record to establish when plants were first used for medicinal purposes, the use of plants as healing agents is an ancient practice. Over time through emulation of the behavior of fauna, a medicinal knowledge base developed and was passed between generations. As tribal culture specialized specific castes, Vaidyas, Shamans and Apothecaries performed the ‘niche occupation’ of healing.
By working with, and not against nature, we increase our chance of a more wholesome life, whereas decreasing our threat of illness and untimely bodily limitations and dysfunctions. A wealth of therapeutic resources is there for the taking, if we however open our eyes to the probabilities available to us.
This book is about one such molecule resourced from plant the Mandelic acid. This book also emphasizes the use of white biotechnology for synthesis of Mandelic acid. We have prepared this book for the benefit of researchers as well as the industries involved in uses and synthesis of Mandelic acid. Moreover, this molecule is finding many other avenues to express its utility. We hope that this book will be a good support for them.
Madhuri Sharon
Annika Durve
Anuradha Pandey
Manish Pathak
Place: Mumbai
Date: 1st December 2013
I
MANDELIC ACID: PHYSICS AND CHEMISTRY
Content:
1.1 Introduction
1.2 Structure of Mandelic acid
1.3 Properties f Mandelic acid
1.4 Conclusion
1.1 INTRODUCTION
42909.pngChemistry has been known to mankind since time immemorial. Recorded use of knowledge of chemistry goes back to 4000 BC. As early as 3000 years ago leather tanning, fruit and grain fermentation and production of copper, iron and steel, brass, silver and gold and their alloys were known to the Vedic Aryans. Moreover, mention of an intoxicant Somarasa in Rig-Veda is the earliest evidence of fermentation process used in India. Indian steel was highly esteemed in the ancient world because of the heights attained by Indians in metallurgy and engineering. This is evident by the discovery of the almost pure copper stature of Buddha found at Sultanganj and the famous iron Pillar at Mehrauli (Delhi which has been able to withstand rain and weather for centuries without rusting).The Harappan remains of 2500 B.C shows developed metallurgy of copper and bronze. By 1000 BC ancient chemists were extracting metal from their ores, making pottery and glazes, fermenting beer and wine, making pigments for cosmetics and painting, extracting chemicals from plants for various uses.
image005.jpgKnowledge of Chemistry has fascinated and evolved through the ages and the progress in the direction of revealing the science of Chemistry is continual. The present book is one such effort to understand and use the intricacies of chemistry for production of Mandelic acid.
Plants have always been envisaged at the source of useful chemicals. One such plant is Bitter almond or as called in German language Mandel. Mandelic acid was discovered while heating amygdalin, (a cyanogenetic glycoside found in many plants including bitter almond, apricot, and wild cherry) an extract of bitter almonds, with diluted hydrochloric acid by Walker and Krieble (1909). Its name is derived from the source plant i.e. Mandel. Mandelic acid is an aromatic alpha hydroxyl acid (AHA) with the molecular formula C6H5CH (OH) COOH. Mandelic acid gained commercial importance with its introduction in cosmetic industries, in the early 1990s, for improving the texture of the skin and reducing the signs of wrinkles.
52092.pngFigure 1.1 – A–Almond on tree and B-Almonds: the first known source of Mandelic acid
1.2 STRUCTURE OF MANDELIC ACID
Mandelic acid is chemically known as alpha hydroxyl benzene acetic acid. Mandelic Acid is a phenylglycollic acid, which has a hydroxyl group on the carbon atom next to the acid group. It is an 8-carbon alpha-hydroxy acid with the chemical formula HOCH (C6H5) COOH. These Alpha Hydroxy acids or ‘AHA’s are aromatic compounds which occur naturally. Mandelic acid is the smallest aromatic AHA; though it is larger than Glycolic acid, the most popular alpha hydroxy acid. The synonyms used for Mandelic acid are amygdalic acid, uromaline, (S)-alpha-hydroxyphenylacetic acid, 2-phenylglycolic acid, Acido Mandelico, alpha hydroxyl benzene Acetic acid.
image010%20copy.jpgFigure 1.2 -Mandelic Acid (Molecular formula: C8H8O3)
AHA has dual functionality of acid and alcohol. It has a hydroxyl