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The psychiatry field is buzzing with anticipation — and hesitation — about esketamine for depression

Many experts have lauded esketamine as an important option for patients with depression, but others aren’t convinced there’s enough data to show it is effective.

The Food and Drug Administration is expected to decide in the coming weeks whether to approve esketamine, which would become the first major depression treatment to hit the market in decades. The psychiatry field is buzzing with excitement — and hesitation.

Esketamine — developed by Johnson & Johnson and delivered as a nasal spray — would be used in combination with oral antidepressants in patients with depression that haven’t responded to other drugs. Many experts have lauded esketamine as an important option for patients in dire need of new treatments — particularly because it could work faster than existing antidepressants.

An independent advisory committee convened by

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