TIME

THE DRUG CASCADE

A boom in prescription painkillers drove the opioid crisis. Now there are pills to solve it

OPIOID-INDUCED CONSTIPATION

AMITIZA

MEDICATION _ Lubiprostone

COMPANY _ Sucampo Pharmaceuticals and Takeda Pharmaceuticals U.S.A.

OVERDOSE TREATMENT

NARCAN

MEDICATION _ Naloxone hydrochloride

COMPANY _ Opiant Pharmaceuticals and Adapt Pharma

OPIOID ADDICTION TREATMENT

REVIA

MEDICATION _ Naltrexone

COMPANY _ Duramed Pharmaceuticals

OPIOID-INDUCED CONSTIPATION

RELISTOR

MEDICATION _ Methylnaltrexone bromide

COMPANY _ Progenics Pharmaceuticals and Salix Pharmaceuticals

OVERDOSE TREATMENT

EVZIO

MEDICATION _ Naloxone hydrochloride

COMPANY _ Kaléo

OPIOID ADDICTION TREATMENT

VIVITROL

MEDICATION _ Naltrexone

COMPANY _ Alkermes

OPIOID ADDICTION TREATMENT

SUBOXONE

MEDICATION _ Buprenorphine/Naloxone

COMPANY _ Indivior

OPIOID-INDUCED CONSTIPATION

MOVANTIK

MEDICATION _ Naloxegol

COMPANY _ AstraZeneca and Daiichi Sankyo

WHEN IT COMES TO KILLING PAIN THESE DAYS, A PRESCRIPTION FOR A HIGH-POWERED opioid is no longer enough. Once you’re taking, say, OxyContin or hydrocodone on a regular basis, you’ll probably get pills for the side effects: pills to control the nausea, pills to regulate your testosterone production, and pills to help you use the bathroom when the drugs numb the receptors in your intestines that are supposed to help move things along.

If you become addicted to painkillers, there are pills to help you stop taking the pills, by reducing the symptoms of withdrawal. And if you take too many pills, there’s a pill for that too. Or, rather, there’s a nasal spray, or an injection, or a nifty $4,100 auto-injector that announces, through a tiny speaker, how to

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