In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden interviews Dr. Mariza Snyder about perimenopause and hormone replacement therapy. Dr. Mariza shares her personal experience with perimenopause and her mother's struggle with severe mood changes. They discuss the impact of stress on hormone levels and the importance of progesterone in maintaining hormonal balance. They also touch on the remodeling of the brain during perimenopause and the potential benefits of hormone replacement therapy in reducing the risk of dementia. In this conversation, Dr. Mariza and Dr. Gladden discuss the use of hormone replacement therapy (HRT) for women experiencing perimenopause and menopause. They emphasize the importance of treating the individual rather than relying solely on lab results. Dr. Mariza shares her recommendation on when to test women during their menstrual cycle. They also discuss the potential for extending longevity by developing molecules that enable ovaries to function longer. They highlight the significance of lifestyle factors, such as metabolic health, inflammatory markers, and nutrient profiles, in optimizing women's health. Additionally, they touch on the importance of monitoring cancer risk and managing hormone metabolism through gut health and liver detox pathways. They stress the need for comprehensive testing and individualized treatment plans to ensure the safe and effective use of hormone replacement therapy.   Takeaways   ·      Perimenopause is a time of hormonal transition for women, typically starting in their late 30s or early 40s. ·      Symptoms of perimenopause can include mood swings, anxiety, brain fog, heavy periods, bloating, and sleep issues. ·      Progesterone plays a crucial role in maintaining hormonal balance and can help alleviate symptoms of perimenopause. ·      Hormone replacement therapy, including progesterone supplementation, may be beneficial in optimizing hormone levels and reducing the risk of dementia. ·      The remodeling of the brain during perimenopause can have significant impacts on a woman's overall health and well-being. Hormone replacement therapy (HRT) can be beneficial for women experiencing perimenopause and menopause. ·      Treating the individual and monitoring symptoms is important, rather than relying solely on lab results. ·      Testing hormone levels, including estrogen metabolism, progesterone, estradiol, estrone, testosterone, and DHEA, can provide valuable insights. ·      Lifestyle factors, such as metabolic health, inflammatory markers, and nutrient profiles, play a significant role in women's overall health. ·      Monitoring cancer risk and optimizing hormone metabolism through gut health and liver detox pathways is crucial. ·      Comprehensive testing and individualized treatment plans are necessary for safe and effective hormone replacement therapy.   Chapters   00:00 Introduction and Personal Experience with Perimenopause 11:57 The Role of Progesterone in Balancing Hormones 30:00 Delaying Menopause and Extending Longevity   To follow Dr. Mariza and her work or reach out to her: ·      Facebook: https://www.facebook.com/drmarizasnyder/  ·      Instagram: https://instagram.com/drmariza/  ·      YouTube: https://www.youtube.com/user/drmarizasnyder  ·      Twitter: https://twitter.com/DrMariza   ·      Website: https://www.drmariza.com/  ·      Email: mariza@drmariza.com    For the audience: ·      Dr. Mariza wants to gift you the Women’s Metabolic Assessment Guide + Functional Lab Ranges! Get it here → https://drmariza.com/metabolicassessment  ·      Use the code 'Podcast10' to get 10% OFF your order at our supplement store → https://gladdenlongevityshop.com/     Reach out to us: Website: https://gladdenlongevity.com/ Email: podcast@gladdenlongevity.com Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://ww