A rapid review of gender-affirming mastectomy for the plastic surgery learner. In this episode we review:WPATH criteria for gender-affirming mastectomyEvaluation and management of the gender-affirming mastectomy patientFeedback is always appreciated. Comments, questions, suggestions, or corrections can be sent to jakemarksmd@gmail.comReferences:Safa B, Lin WC, Salim AM, Deschamps-Braly JC, Poh MM. Current Concepts in Masculinizing Gender Surgery. Plast Reconstr Surg. 2019;143(4):857e-871e.Salibian AA, Axelrod DM, Smith JA, Fischer BA, Agarwal C, Bluebond-Langner R. Oncologic Considerations for Safe Gender-Affirming Mastectomy: Preoperative Imaging, Pathologic Evaluation, Counseling, and Long-Term Screening. Plast Reconstr Surg. 2021;147(2):213e-221e.Hontscharuk R, Alba B, Manno C, et al. Perioperative Transgender Hormone Management: Avoiding Venous Thromboembolism and Other Complications. Plast Reconstr Surg. 2021;147(4):1008-1017.