Holden Karnofsky is the co-CEO of Open Philanthropy and co-founder of GiveWell. He is also the author of one of the most interesting blogs on the internet, Cold Takes.We discuss:* Are we living in the most important century?* Does he regret OpenPhil’s 30 million dollar grant to OpenAI in 2016?* How does he think about AI, progress, digital people, & ethics?Highly recommend!Watch on YouTube. Listen on Apple Podcasts, Spotify, or any other podcast platform. Read the full transcript here.Timestamps(0:00:00) - Intro(0:00:58) - The Most Important Century(0:06:44) - The Weirdness of Our Time(0:21:20) - The Industrial Revolution (0:35:40) - AI Success Scenario(0:52:36) - Competition, Innovation , & AGI Bottlenecks(1:00:14) - Lock-in & Weak Points(1:06:04) - Predicting the Future(1:20:40) - Choosing Which Problem To Solve(1:26:56) - $30M OpenAI Investment(1:30:22) - Future Proof Ethics(1:37:28) - Integrity vs Utilitarianism(1:40:46) - Bayesian Mindset & Governance(1:46:56) - Career Advice Get full access to Dwarkesh Podcast at www.dwarkeshpatel.com/subscribe