Dr. G.S. Raju, editor of the Gastro Grand Rounds section in Gastroenterology, is joined by Drs. Marwan Ghabril and Naga Chalasani to discuss their Gastro Grand Rounds article, "A 68-Year-Old Woman With Unexplained Liver Enzyme Elevation and Active Chronic Hepatitis: Beware of Drug-Induced Autoimmune-Like Hepatitis." https://www.gastrojournal.org/article/S0016-5085(23)05078-3/fulltext

Dr. Ghabril is a professor of medicine at Indiana University School of Medicine. Dr. Chalasani is the David W. Crabb professor of gastroenterology and hepatology and an adjunct professor of anatomy, cell biology, and physiology at Indiana University School of Medicine.

[0:27] Introduction of the authors and outline of the case.
[3:30] Initial thoughts from the authors upon patient presentation.
[7:29] After considering additional patient history, what do the authors think about the patient?
[10:34] Does the family history of the patient cause the authors to refine the diagnosis?
[11:52] Further thoughts from the authors after physical examination of the patient.
[14:47] What tests are recommended?
[18:55] Additional thoughts from the authors after further testing.
[21:06] Should we be testing for hepatitis E?
[22:56] Should noninvasive testing be used?
[25:11] What is the authors' plan to determine next steps?
[27:06] How long should the wait be before a biopsy?
[29:08] The patient underwent liver biopsy. How were the results interpreted?
[34:31] How long does it take to determine that an appropriate course of action was made?
[35:37] How is the patient counselled?
[38:43] The LiverTox database.
[41:41] Final thoughts from the authors.

Thank you for listening. Find this and other articles on our website at https://www.gastrojournal.org. We welcome your feedback. Please email us at gastro@gastro.org.

This discussion was recorded on Dec. 20, 2023, and reflects medical knowledge at that time. The views and opinions expressed in this podcast are those of the individual speakers only and do not necessarily represent those of the American Gastroenterological Association. The content of this podcast is provided for general information purposes only and does not offer medical or any other type of professional advice.