Today, we’re talking with The Gene Queen Sarah Morgan about … Unlocking the Choline Connection: A Key to Alzheimer's Puzzle in Women - Decoding Its Impact, Genetic Factors, and Vital Strategies for Optimal Brain Health. Key Points Women may go into pregnancy choline deficient and have huge demand in pregnancy and lactation.  In perimenopause. Estrogen levels decline. PEMT activity declines. Why? Estrogen is an inducer of PEMT activity. Low estrogen = Low choline production  Memory declines, sleep worsens. We may increase the risk of Alzheimer’s over decades through choline deprivation.  Key gene = PEMT (rs7946 and rs12325817)