Dr. Leigh J. Mack, was clinically trained in trauma and plastic surgery and is boarded as clinical research physician. He has designed many trials in the areas of pulmonary devices, aesthetic medicine (injectables), infectious disease nano-particles, medical lasers and other devices.  He was recently a physician advisor to a 20-hospital healthcare system in utilization review and appeals.  He has designed an automated software system for participant recruitment that employs RPA to search 100,000s of EMR records in a few days time to meet potential participants for clinical trials. In 2021, he left the position of Chief Medical officer for Crucial Data Solutions and started to develop his own clinical trial software that employs RPA, micro-services and block chain type technology. He also severed in the SC State Guard as the G-7 Civil Affairs officer. This week we discuss what protocol development can learn from military planning, using AI to identify clinical trial participants and the role of pharmacogenetics in clinical trials.