In Episode 12, Dr. William Cushman, co-investigator of the 2015 SPRINT (Systolic Blood Pressure Intervention) Trial, joins us for a discussion all about hypertension trials, their long history, and what's ahead for research in this space. Too young to remember SPRINT or looking for a "CliffsNotes" of HTN trials? This episode's for you!Here's a Renal Fellow Network post from 2017 with a link to a cheat sheet of hypertension clinical trial.Nephrons: Matthew Sparks, Samira FaroukGuests: William Cushman, Medical Director & Professor, Department of Preventive Medicine, University of TennesseeLinks from the Show:00:41: Systolic Blood Pressure Intervention Trial (2015)02:17: VA Cooperative Study (1967)05:13: ACCORD Study (2010)06:30: SPRINT MIND (2019)08:40: Framingham Heart Study (Started 1948)11:27: Attended vs. unattended blood pressure – learnings beyond SPRINT (2021)14:03: Systolic Hypertension in the Elderly Program Study (1989)14:05: Hypertension Detection & Follow Up Program (1979)15:32: JNC 8 Guidelines (2014)16:01 AHA/ACC Guidelines (2017)17:54: Syst-Eur (Treatment of HTN in Patients > 60 y, 1998)17:54: HYVET (Treatment of HTN in Patients > 80 y, 2008)18:01: Syst-China (2000)22:18: AAFP HTN Guidelines (2022)22:40: KDIGO HTN Guidelines (2021)25:37: ALLHAT Study (2002)32:22: Secondary Prevention of Small Subcortical Strokes Trial (SPS3, 2013)