Moderator: Antonio Malvaso (Pavia, Italy)Guest: Alberto Vogrig (Udine, Italy)In this episode of EAN Cast Weekly Neurology, Dr. Antonio Malvaso, a neurology resident, welcomes Dr. Alberto Vogrig, an international expert in the field of paraneoplastic neurological syndromes. They discuss the definition of these syndromes, emphasizing the causal relationship with cancer and their immune-mediated pathogenesis. They also talk about the revised diagnostic criteria and the importance of clinical diagnosis, laboratory techniques, and oncologic screening. The treatment for these syndromes includes immunosuppression, cancer therapy, and symptomatic treatment, tailored to the specific symptoms.