Remembering a critical breakthrough in diabetes research on a fateful night over 100 years ago, Anand E. Rajesh and Aaron Y. Lee on the incredible potential of artificial intelligence in screening for and diagnosing diabetic retinopathy, Brigitte I. Frohnert on stage 1 type 1 diabetes and multiple islet autoimmunity, and more! Welcome to episode no. 11 (October 2023) of Diabetes Care “On Air”—a new and different way to bring the research published in Diabetes Care to life. Join co-hosts Alice Cheng, MD, FRCPC, and Michael Rickels, MD, MS, as they discuss the latest and greatest content in the October 2023 issue of Diabetes Care.   0:45: Alice kicks off the episode with a fun October fact about a critical breakthrough in diabetes research that occurred in 1920. This breakthrough came in the form of an idea in a dream of Sir Fredrick Banting in the early morning hours of Halloween that year, and this idea contributed greatly to the discovery and successful purification of insulin. 2:20: Alice interviews Anand E. Rajesh and Aaron Y. Lee, authors of “Artificial Intelligence and Diabetic  Retinopathy: AI Framework, Prospective Studies, Head-to-head Validation, and Cost-effectiveness” This study is an editor-selected feature article appearing in the October 2023 issue and is openly accessible at https://doi.org/10.2337/dci23-0032.    22:54: Mike interviews Brigitte I. Frohnert, lead author of “Refining the Definition of Stage 1 Type 1 Diabetes: An Ontology-Driven Analysis of the Heterogeneity of Multiple Islet Autoimmunity.” This study is also an editor-selected feature article appearing in the October 2023 issue and is openly accessible at https://doi.org/10.2337/dc22-1960. 43:36: In the “Diabetes Care Rapid Exchange,” Alice and Mike wrap up the episode by reviewing several interesting articles in the October 2023 issue of Diabetes Care. Studies highlighted in this segment include: Sacks et al. Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus. https://doi.org/10.2337/dci23-0036    Speksnijder et al. Effect of Postmenopausal Hormone Therapy on Glucose Regulation in Women With Type 1 or Type 2 Diabetes: A Systematic Review and Meta-analysis. https://doi.org/10.2337/dc23-0451   Ahmed et al. Genetic Evidence Strongly Supports Managing Weight and Blood Pressure in Addition to Glycemic Control in Preventing Vascular Complications in People With Type 2 Diabetes. https://doi.org/10.2337/dc23-0855   Wei et al. All-Cause Mortality and Cardiovascular and Microvascular Diseases in Latent Autoimmune Diabetes in Adults. https://doi.org/10.2337/dc23-0739    Osafehinti et al. Type 1 Diabetes Genetic Risk Score Differentiates Subgroups of Ketosis-Prone Diabetes. https://doi.org/10.2337/dc23-0622   Berg et al. A Skin Care Program to Prevent Skin Problems due to Diabetes Devices in Children and Adolescents: A Cluster-Controlled Intervention Study. https://doi.org/10.2337/dc23-0462     To learn more about Diabetes Care, please visit diabetesjournals.org/care. Interested in submitting cover art to the journal? Please visit https://diabetesjournals.org/care/pages/submit_a_cover_image.