Deion Sanders and the Colorado Buffaloes face their biggest test of the season against the Oregon Ducks. The Ole Miss Rebels and The Alabama Crimson Tide clash in a ranked vs. ranked SEC battle. The Penn State Nittany Lions have a chance to prove they are one of the best teams in the country as they host the Iowa Hawkeyes in a classic White Out game. College Football Kickoff Live goes around the college landscape, breaking down all the big matchups in the SEC, BIG 10, BIG 12, PAC-12, Sun Belt and HBCU.

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