When is a non-diagnostic biopsy a good thing? And when should you go back? This week Wende Gibbs discusses a classic paper describing tips and decision making for musculoskeletal biopsies. And Ross Frederick discusses a useful new article on sphenoid wing lesions. Anatomy and Diseases of the Greater Wings of the Sphenoid Bone. Cochinski et al. RadioGraphics 2022; 42:0000–0000. Pearls and Pitfalls for Soft-Tissue and Bone Biopsies: A Cross-Institutional Review. Meek et al.  RadioGraphics 2020; 40:266–290.