Amyloid—the devious protein that when misfolded can cause serious incurable disease in nearly every body system. Wende Gibbs discusses a new article about amyloidosis, and Ross Frederick summarizes a new Rad-Path article on pituitary gland tumors in this week's RadioGraphics podcast.  Amyloidosis: Multisystem Spectrum of Disease with Pathologic Correlation. Sugi et al. RadioGraphics 2021; 41:1454–1474 Primary Tumors of the Pituitary Gland: Radiologic-Pathologic Correlation. Shih et al. RadioGraphics 2021; 41:2029–2046