COVID-19 can have a negative impact on systems throughout the body, beyond just the lungs, according to a review published in Nature Medicine. Two authors of the review joined host David H. Henry, MD, to discuss their article, “Extrapulmonary manifestations of COVID-19.”  Aakriti Gupta, MD, of Columbia University Irving Medical Center, and Kartik Sehgal, MD, of Dana Farber Cancer Institute, discussed: ACE2, the entry receptor for SARS-CoV-2 Neurologic and gastrointestinal manifestations of COVID-19 Mechanisms of coagulation and thromboprophylaxis COVID-19 in cancer patients The impact of quarantine on cardiology patients The lasting effects of COVID-19 and the need for follow-up The importance of international collaboration for clinical trials. For more details on how COVID-19 can affect the body, see the full review in Nature Medicine: Gupta A. et al. Nat Med. 2020 Jul;26(7):1017-1032.  Disclosures: Dr. Henry and Dr. Sehgal have no financial disclosures relevant to this episode. Dr. Gupta disclosed relationships with the Arnold & Porter Law Firm for work related to the Sanofi clopidogrel litigation, the Ben C. Martin Law Firm for work related to the Cook inferior vena cava filter litigation, Edward Lifesciences, and Heartbeat Health. * * *  For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgehemonc David Henry on Twitter: @davidhenrymd