with @mclader @smc90 In this wide-ranging conversation, Uniswap Labs COO Mary Catherine (aka MC) Lader discusses the challenges -- and opportunities -- of decentralized finance (DeFi); business strategy (& competition) in a world of open source; product vs. protocol innovation... as well as organizational structure & collaboration, hiring, metrics, community engagement, app store policies, decentralization, and much, much more. The conversation -- based on an interview with host Sonal Chokshi and founder Q&A live from a16z crypto Startup School earlier this year -- also covers how to make decisions on what to innovate on or not; how to move from  idea and vision to business; and the transition overall from traditional finance/ tradfi. Before joining Uniswap Labs (which contributes to Uniswap, a protocol for trading and automated liquidity provision on Ethereum) -- Lader was a managing director at BlackRock (and chief operating officer of the firm’s digital wealth business and head of its climate tech business); was formerly a fintech entrepreneur; and began her career as an investment analyst at Goldman Sachs. ---As a reminder: none of the following should be taken as investment, legal, business, or tax advice; please see a16z.com/disclosures for more important information -- including a link to a list of our investments.