In this episode of SurgOnc Today®,  Dr. Judy Boughey, from the Mayo Clinic, in Rochester, MN and Dr. Carlos Garcia-Etienne, from the Ospedale Santa Chiara in the Autonomous Province of Trento, Italy review three practice changing studies and how their findings are important to breast surgical oncologists. During the podcast, they will review: Effectiveness of Breast-Conserving Surgery and 3-Dimensional Conformal Partial Breast Reirradiation for Recurrence of Breast Cancer in the Ipsilateral Breast: The NRG Oncology/RTOG 1014 Phase 2 Clinical Trial (JAMA Oncol. 2020 Jan 1;6(1):75-82. doi: 10.1001/jamaoncol.2019.4320.) Pembrolizumab for Early Triple-Negative Breast Cancer (N Engl J Med 2020; 382:810-821 DOI: 10.1056/NEJMoa1910549.) Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer (N Engl J Med. 2021 Jun 24;384(25):2394-2405. doi: 10.1056/NEJMoa2105215.)