Nick talks to biochemist & biophysicist Dr Ryan Gumpper, a postdoc in Dr. Bryan Roth's lab at the University of North Carolina. They discuss the biochemistry, molecular biology & biophysics of serotonin receptors, including the molecular details for what happens when serotonin and tryptamines psychedelics (e.g. LSD) bind to 5HT2A receptors in the brain. They also discuss how understand these details relates to the quest to discover novel psychedelic-derived compounds with therapeutic benefits, as well as the inspiration Ryan received from reading Alexander Shulgin's famous book, PIHKAL.Support the showSign up for the free weekly Mind & Matter newsletter:[https://mindandmatter.substack.com/?sort=top]Learn how you can further support the podcast: [https://mindandmatter.substack.com/p/how-to-support-mind-and-matter]Become a Premium Subscriber to access full content library, including full premium episodes:[https://mindandmatter.substack.com/subscribe?utm_source=menu&simple=true&next=https%3A%2F%2Fmindandmatter.substack.com%2F]Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off:[https://www.lumen.me/shop?fid=8731&utm_source=influencer&utm_medium=influencer&discount=MIND]