Nick talks to Christian Lüscher, MD, PhD, a neuroscientist at the University of Geneva whose lab studies the cellular mechanisms that underlie drug reinforcement, dependence and addiction. Dr. Lüscher talks about the nature of addictive drugs in the brain, how ketamine works, and the latest research from his lab look at how ketamine's unique effects within the brain's reward circuitry enable it to be psychoactive & reinforcing, but have a very low addiction liability (in rodents). He also discusses what this research may mean for the use of ketamine as a therapeutic treatment for depression in humans. Support the showSign up for the free weekly Mind & Matter newsletter:[https://mindandmatter.substack.com/?sort=top]Learn how you can further support the podcast: [https://mindandmatter.substack.com/p/how-to-support-mind-and-matter]Become a Premium Subscriber to access full content library, including full premium episodes:[https://mindandmatter.substack.com/subscribe?utm_source=menu&simple=true&next=https%3A%2F%2Fmindandmatter.substack.com%2F]Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off:[https://www.lumen.me/shop?fid=8731&utm_source=influencer&utm_medium=influencer&discount=MIND]