This episode is part of a live recording for our NEURO Academy community, and the topic of the discussion is the genetics of Alzheimer’s disease, in particular a deep dive into Apolipoprotein E4 or APOE4 gene, which is the most influential genetic risk factor associated with Late Onset Alzheimers Disease.  We describe the evolutionary aspects of Apolipoproteins, how they are produced, how the different isoforms of apoe influence the different factors leading to AD, how it effects lipid metabolism and immune functions in the brain, and what is the latest evidence on the epigenetic of APOE4. Typically, the community members post their questions ahead of time and we structure the conversation in a way to address their questions, and also answer their questions during the recording.    NEURO Academy is a membership based online community with over 700 active members, with resources to achieve optimal brain health, better cognition and prevent cognitive decline. The platform provides the opportunity to connect with us and an empowering community, and participate in weekly live Q&A sessions, education on evidence based nutrition and other lifestyle factors, live cooking demonstration , live podcasts and Q&A with remarkable health leaders, interest groups, book clubs, science club discussions, access to on-demand courses on prevention of neurological diseases,  evidence-based nutrition and cooking, behavioral sciences and many others on various topics related to brain health. Members can receive CE or CME credits and certification after taking the course. Join us by visiting NEUROacademy.com.   Follow us: Join the NEURO Academy: NEUROacademy.com Follow us on social media: Instagram: The Brain Docs @thebraindocs YouTube: The Brain Docs Facebook: The Brain Docs TikTok: @thebraindocs Website: TheBrainDocs.com