In this interview, Dr. Nadia Fairbairn and Dr. Christy Sutherland discuss how to treat opioid use disorder with injectable opioid agonist treatments. They discuss which patients are good candidates for the treatment, how the treatment is administered, and they offer practical advice on overall strategies for treatment and support for patients with opioid use disorder. They also discuss the opioid epidemic on a systemic level.Dr. Nadia Fairbairn is an internist who specializes in addiction medicine at St. Paul’s Hospital in Vancouver and is director of the International Collaborative Addiction Medicine Research Fellowship with the BC Centre on Substance Use.Dr. Christy Sutherland is a family physician in downtown Vancouver who specializes in addiction medicine. She has lead a number of initiatives to help downtown Vancouver’s most vulnerable residents.To read the clinical practice guideline: www.cmaj.ca/lookup/doi/10.1503/cmaj.190344Podcast transcript: https://www.cmaj.ca/transcript-190344-----------------------------------Subscribe to CMAJ Podcasts on Apple Podcasts or your favourite podcast app. You can also follow us directly on our SoundCloud page or you can visit www.cmaj.ca/page/multimedia/podcasts.