Pyrrole Disorder has gained some notoriety in integrative medicine because it's often uncovered via screening of patients with mood or "disorders of socialisation" - particularly in children. The clinical presentation of Pyrrole Disorder has a close relationship with methylation and Dr Mark Donohoe articulates this relationship with poise. His overwhelming take-home message is that we cannot simply take a reductionist approach when treating those who present with pyroluria by boosting them up with the required nutrients but that we must look at the bigger picture and take a broader approach in the healing journey of these patients.