The relationship between the gut and the immune system is one of the most exciting and clinically relevant areas of research in molecular medicine. We have learnt that disturbances in gut homeostasis and microbial balance can activate the innate immune system in several ways causing wide and systemic dysfunction. In this interview Mike Ash, an immunologist and naturopath, discusses the latest research in this field. He explains how you can use gastrointestinal immunology to enhance mitochondria and consequently reduce activation of the innate immune system, reduce oxidative stress and reduce inflammation. Mike Ash presents a compelling view of how gut can be a point of intervention for the safe treatment of chronic disease while providing an opportunity for multiple organ system resolution.