The rapid development of the mRNA covid vaccine shows that breakthrough innovation can happen at great pace when needed - so what’s holding us back in other areas? How can the world – and business – deliver transformational new technologies at speed?  Drawing on lessons from the development of other breakthrough technologies, Chief Operating Officer of Wellcome Leap and former acting director of the United States’ Defense Advanced Research Projects Agency (DARPA), Ken Gabriel, talks about the recipe for breakthrough, rather than incremental, innovation.  He is joined by PwC UK’s Leo Johnson, Head of Disruption & Innovation, to discuss the future of innovation for some of society’s biggest challenges and the crucial issue of trust.