E43: Tofacitinib for MDA5 Amyopathic Dermatomyositis ILD

FromThe Evidence Based Rheumatology Podcast

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E43: Tofacitinib for MDA5 Amyopathic Dermatomyositis ILD

FromThe Evidence Based Rheumatology Podcast

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Length:

12 minutes

Released:

Aug 8, 2019

Format:

Podcast episode

Description

Back this week to discuss an interesting paper in the NEJM. Lots of interesting issues, most notably historical controls and their limitations. Find all my work at ebrheum.com!

Released:

Aug 8, 2019

Format:

Podcast episode

Titles in the series (87)

A weekly podcast for physicians interested in evidence based medicine and rheumatology. Find the papers at ebrheum.com

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E6: Methylprednisolone and Cyclophosphamide, Alone or in Combinatinon, for Lupus Nephritis: Welcome back! Before we talk about cellcept for lupus nephritis, I decided we should flash back to 1996 and discuss one of the early trials that brought us cyclophosphamide. It's a quick discussion that will help set us up nicely for ALMS this Sunday. ... by The Evidence Based Rheumatology Podcast
9 min listen
E26: Housekeeping 1: Every 25 episodes I'd like to step back and touch base about where the podcast is headed. Thanks to everyone who has been listening! Apologies for nothing exciting or useful this week. by The Evidence Based Rheumatology Podcast
4 min listen
E17: Steroids and the Risk of Scleroderma Renal Crisis: Short but impactful paper this week on the association between steroids and scleroderma renal crisis. Find the original paper here. by The Evidence Based Rheumatology Podcast
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E8: Mepolizumab or Placebo for EGPA: This week we'll discuss a recent trial on mepolizumab - and IL-5 inhibitor - for eosinophilic granulomatosis with polyangiitits. Find the paper here and be sure to follow us on twitter @JBRheum! by The Evidence Based Rheumatology Podcast
14 min listen
E7: The ALMS Trial - MMF vs CYC for Lupus Nephritis: Today we'll be discussing the ALMS trial, which pitted cellcept against cyclophosphamide. It's a good trial that has had profound influences on our practice and well worth a read. Access the paper itself here. by The Evidence Based Rheumatology Podcast
10 min listen
E13: Withdrawing HCQ in SLE: Short podcast today on an old RCT addressing the utility of hydroxychloroquine (plaquenil) in lupus. It's an oldie but goodie and one that I enjoyed talking about. by The Evidence Based Rheumatology Podcast
11 min listen
E22: Ustekinumab for Giant Cell Arteritis: Quick episode today on a small prospective trial on ustekinumab for giant cell arteritis. Papers can all be found here! by The Evidence Based Rheumatology Podcast
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E36: Baricitinib for SLE: This week I discuss the phase 2 trial on baricitinib in SLE. Though it's early times (and the total flop of rituxan in ME/CFS recently can attest to this), this was a large phase 2 and I'm hopeful it carries through to the ongoing phase 3 trials. Follo... by The Evidence Based Rheumatology Podcast
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E9: Rituximab in Myositis - The RIM Trial: This week we'll discuss a randomized controlled-ish trial, the RIM study. It pits rituximab against placebo as well as... rituximab? We'll talk about how their design convincingly demonstrated that ritixan does not have a benefit over placebo for 8 week... by The Evidence Based Rheumatology Podcast
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E12: ACR 2015 Workforce Study - the Rheumageddon!: This week we'll discuss the recently published ACR Workforce Study, which estimates a substantial deficit in the workforce by 2030. We'll consider how dire the situation actually is - checkout the paper itself here. by The Evidence Based Rheumatology Podcast
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E19: Clinical Utility of a Positive ANA: Quick podcast this week on the utility of an ANA. It's a frequent reason for referral (17% in this series) to rheumatology offices and this is a useful paper for context. Find the paper itself here. by The Evidence Based Rheumatology Podcast
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E25: MAINRITSAN 2 - Fixed vs. Tailored Rituxan for AAV: Interesting trial this week evaluating a fixed schedule of rituximab vs. a tailored approach to therapy. See you all at ACR this week! by The Evidence Based Rheumatology Podcast
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E10: Abatacept in RA-ILD: Quick podcast tonight reflecting the Rheumatology Journal Club (@RheumJC) discussion! I joined as they discussed the use of abatacept in patients with rheumatoid arthritis who develop ILD. It's our first observational trial, so it's ripe for critique! F... by The Evidence Based Rheumatology Podcast
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E44: SELECT-COMPARE Upadacitinib (JAKi) for Rheumatoid Arthritis: Finally got around to tackling the JAKi this week. I decided to focus on SELECT-COMPARE, which pitted upadacitinib (selective JAK1 inhibitor) against adalimumab and placebo. I briefly discuss other JAKs and my thoughts on the future of this area. Get t... by The Evidence Based Rheumatology Podcast
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E14: Cardiovascular Safety of Febuxostat: Today we'll discuss an important trial on febuxostat (ulloric), which raises important concerns about its safety from a cardiovascular perspective. Be sure to tune in to the #RheumJC discussion that will be happening this Thursday! by The Evidence Based Rheumatology Podcast
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E34: Leggo my Eggo! Eggs, Cholesterol, CVD, Mortality: In this week's episode I depart briefly from discussing papers in the rheumatology literature to dive headfirst into the recent controversy over eggs and cardiovascular disease. Our patients eat eggs too, so I figured it would still be applicable. Please... by The Evidence Based Rheumatology Podcast
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E16: Tocilizumab in Giant-Cell Arteritis - GIACTA: Getting back to our usual format, this week we'll discuss the GIACTA trial, which compared various schedules of tocilizumab to various schedules of placebo and prednisone. It's an important trial that has changed the face of GCA and will be a refreshing... by The Evidence Based Rheumatology Podcast
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E41: Rheum4Debate "SLE Pts. on Cytoxan Should Receive Bactrim": Welcome back! This is the second episode of Rheum4Debate, an oxford-style debate show for the field of rheumatology. In this podcast we'll tackle the question of bactrim prophylaxis in patients receiving cyclophosphamide. The motion was: “Bactrim pro... by The Evidence Based Rheumatology Podcast
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E31: SEAM and MIPA Trials: MTX vs. ETN for Psoriatic Arthritis: This week we tackle two RCTs and try to figure out what to do with etanercept, methotrexate, and placebo (or the lack thereof). Good opportunity for jumping into more PsA trials in the near future - lots of IL-somethings to talk about! Remember to foll... by The Evidence Based Rheumatology Podcast
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E42: SENSCIS - Nintedanib for Systemic Sclerosis ILD: This week I'll discuss an important paper in systemic sclerosis, the recent SENSCIS trial that compared 150mg nitedanib to placebo. I wind up coming down pretty hard on this drug; I think it's hype has vastly outpaced its utility. Get the paper itself a... by The Evidence Based Rheumatology Podcast
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E43: Tofacitinib for MDA5 Amyopathic Dermatomyositis ILD: Back this week to discuss an interesting paper in the NEJM. Lots of interesting issues, most notably historical controls and their limitations. Find all my work at ebrheum.com! by The Evidence Based Rheumatology Podcast
12 min listen
E15: The Ribosomal P Isn't Useful in NPSLE by The Evidence Based Rheumatology Podcast
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E53: Another Look at Nintedanib for SSc-ILD: This week I go back to a topic from episode 42, the SENSCIS trial and nintedanib for SSc-ILD. The way this medication has been received and a recent article I wrote for The Rheumatologist gave me a nice jumping off point to cover a few more issues from ... by The Evidence Based Rheumatology Podcast
15 min listen
E28: Nurse Run Treat to Target vs. Usual Care? in Gout: Interesting trial this week pitting an elaborate nurse led group against suboptimal usual care. Suboptimal usual care lost pretty badly, but what to make of this? And does it support the rheumatologist side of the treat to target controversy? Listen t... by The Evidence Based Rheumatology Podcast
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E51: Rheum4Debate - "Start TCZ Upfront in GCA": Rheum4Debate is back! This week we have Dr. Anisha Dua arguing in support of the motion, "Patients with newly diagnosed GCA should start glucocorticoids WITH tocilizumab over glucocorticoids alone." I argue against the motion and Dr. Sarah Fantus was k... by The Evidence Based Rheumatology Podcast
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E32: TaSER and ARCTIC: U/S to Guide Treatment in Inflammatory Arthritis: Finally addressing this ultrasound business. I decided to cover two somewhat similar trials, which seem to come to the same conclusions regarding U/S and treat to target strategies. However, the question addressed was narrow and the role of ultrasound ... by The Evidence Based Rheumatology Podcast
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E27: Opioids vs. Non-opioids for OA Pain: The SPACE RCT: Great article that (kind of) proves something a lot of us already believed; non-opioids management of chronic pain is preferable to opioid management. Lots of caveats, there, as this was a pragmatic trial (literally) with a number of interesting limitat... by The Evidence Based Rheumatology Podcast
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E23: Stress Related Disorders and Subsequent Autoimmune Disease: Great article this week on stress related disorders and their relationship with subsequent autoimmune disease. One of my favorite recent papers from my least favorite way to do a study! Remember, all my articles can be found here! by The Evidence Based Rheumatology Podcast
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E50: Housekeeping 2: Super brief "checking in" podcast this week. In short, say "hi" at ACR, write me a review on apple podcasts, send this to a friend, and keep listening :). by The Evidence Based Rheumatology Podcast
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E39: MTX for GCA - 3 RCTs and a Case Control Study: This week a nice case control study out of Mayo challenged my own bias against MTX in GCA. This prompted a deep dive into the literature, including 3 RCTs and meta analysis. At the end of the day, I'm more (almost) fully convinced that MTX offers a (me... by The Evidence Based Rheumatology Podcast
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E107: Fragility of SLE Randomized Controlled Trials: Quick methodology episode this week discussing the concept of "fragility" in randomized controlled trials of lupus. Really enjoyed discussing this paper and was grateful to have been a part of it. Get the text here: https://lupus.bmj.com/content/lupu... by The Evidence Based Rheumatology Podcast
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E106: GCA/PMR with Bhaskar Dasgupta: Today I'm taking another twitter discussion into the podcast realm! Dr. Bhaskar Dasgupta has published hundreds of papers about polymyalgia rheumatica and giant cell arteritis, including a recent publication in Nature Reviews: Rheumatology that pique... by The Evidence Based Rheumatology Podcast
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E105: Autoimmunity Post COVID-19?: Interesting topic and interesting paper this year, including discussion of observational biases, positive and negative controls, and interpreting data as it comes. Paper: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2810259 by The Evidence Based Rheumatology Podcast
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E43: Tofacitinib for MDA5 Amyopathic Dermatomyositis ILD

E43: Tofacitinib for MDA5 Amyopathic Dermatomyositis ILD

Description

Titles in the series (87)

More Episodes from The Evidence Based Rheumatology Podcast