This episode helps us understand the concept of autoimmunity first, taking us through the complex pathophysiology of ulcerative colitis. We then discuss intestinal and extra-intestinal manifestations of the disease and an approach to the acute UC flare. Written by: Dr. Anthony Sandre (Internal Medicine Resident) Reviewed by: Dr. Ted Xenodemetropoulos (Gastroenterologist) and Dr. Andrew Cheung (General Internist) Infographic by: Dr. Caitlyn Vlasschaert (Internal Medicine Resident)