In this episode, we review the pathophysiology and diseases associated with chronic diarrhea. We use the MISO acronym to divide up etiologies as well as our work-up. We review basic treatments as well as approaches to symptom management. As always, we have an associated infographic at www.theinternatwork.com. Episode written by: Dr. Sechiv Jugnundan (Internal Medicine Resident)Reviewed by: Dr. Nadia Griller (Gastroenterologist) and Dr. Kevin Venus (General Internist)Sound Editing by: Dr. Nafis Hossain (Internal Medicine Resident)