Dr. Damian Krysan is a physician and an Associate Professor at the University of Rochester Medical Center. Dr. Krysan studies fungi, which in addition to their known roles in e.g. food spoilage and alcohol fermentation, can cause significant disease in humans. Fungi typically cause serious and potentially fatal disease in immunocompromised people, which presents a challenge to the medical community to come up with ways to treat and prevent fungal infections in this population. Dr. Krysan is doing research to identify new anti-fungal medications. Dr. Krysan discusses fungi and fungal infections, the difficulty of identifying new anti-fungal drugs, and his interest in tiny bugs stemming from his father’s career as an entomologist studying bigger bugs. The MicroCase for listeners to solve is about LaFontaine Miraculous, the superstar baseball player with the San Antonio Fire Ants, who comes down with a mysterious illness after riding his ATV. Discussants (in alphabetical order): Dr. Karl Klose (Professor and director of STCEID, UTSA) Dr. Jose Lopez-Ribot (Professor and Associate director of STCEID, UTSA) Dr. Floyd Wormley (Professor, STCEID, UTSA) microTalk is supported, in part, by the American Society for Microbiology. Visit asm.org to discover more microbiology resources and content.