For our third episode, we bring you a birds-eye view of modeling messy biologic systems, namely the brain. Peter Bandettini talks to Danielle Bassett about the challenges of measurement accuracy and what scale might be most informative for modeling, including how to make do with what we have. From the clinical perspective, they talk about network control theory for modulating networks for therapy and discuss limitations in technology. They also talk about the limits of network modeling and the search for the equivalent of an idea as powerful as “natural selection” for the brain. In the second part of the podcast they discuss bias in science and what Danielle is doing to help increase transparency to combat this bias.