Synbio Changes Everything

FromI AM BIO

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Synbio Changes Everything

FromI AM BIO

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Length:

31 minutes

Released:

Sep 21, 2020

Format:

Podcast episode

Description

The ability to produce COVID vaccines in record time only scratches the surface of what synthetic biology can do. Gingko Bioworks out of Boston is now 3-D printing millions of letters of DNA code and then using CRISPR to insert them into living cells, transforming what’s scientifically possible.

Released:

Sep 21, 2020

Format:

Podcast episode

Titles in the series (100)

Powerful stories of biotechnology breakthroughs, the people they help, and the global problems they solve. Hosted by BIO President & CEO Dr. Michelle McMurry-Heath.

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Vaccines are a Virtue: As biotech researchers work around the clock on a covid vaccine, ill-informed, anti-science anti-vaxxers must be denounced and excoriated in the public square. BIO’s head of infectious disease policy Phyllis Arthur administers a vital dose of vaccine education, because none of us is safe until we all are. Hosted by Jim Greenwood. by I AM BIO
33 min listen
Superbuggin’: Incurable gonorrhea and the deadly hospital superbug C. diff offer a frightening window into the gathering public health menace of antibiotic resistance. If society doesn’t wake up and tackle the problem, we could be headed toward a calamity on the magnitude of climate change. Hosted by Jim Greenwood. by I AM BIO
28 min listen
The Antibody Test Shortage: Only antibody testing can tell us who has been infected and recovered from coronavirus and when it might be safe to return to work. There’s a massive global shortage of these tests, and a Maryland biotech is racing to bolster the U.S. supply. Hosted by Jim Greenwood. by I AM BIO
27 min listen
COVID-19’s True Origins (Redux): There's a joke among ecological health scientists that if “you don’t believe one person can change the world, try eating an undercooked bat.” However, what EcoHealth Alliance’s Dr. William Karesh — a world-renowned expert on zoonotic disease transmission — reveals about the trend line for animal-to-human viral transmission is no laughing matter. Hosted by Jim Greenwood. by I AM BIO
39 min listen
Trying our Patients: As genetic sequencing gives scientists new tools to hone in on medical mysteries, Washington politicians flirt dangerously with policies that would stymie the genomic revolution while giving patients scant pricing relief at the pharmacy counter. Hosted by Jim Greenwood. by I AM BIO
36 min listen
Sickle Cell Saviors: Need a dose of inspiration in a time of national tragedy? A remarkable biotech breakthrough from Global Blood Therapeutics offers fresh hope to patients living with sickle-cell disease. Hosted by Jim Greenwood. by I AM BIO
62 min listen
COVID-19: We Were Warned (Redux): For years, leaders on the Bipartisan Commission on Biodefense told Congress and the White House that it wasn’t a matter of if, but when, a pandemic would happen. Exploring the panel’s unheeded recommendations can give the United States a blueprint for what to do going forward to protect us from the coronavirus and future threats. by I AM BIO
50 min listen
COVID-19: We Were Warned: For years, leaders on the Bipartisan Commission on Biodefense told Congress and the White House that it wasn’t a matter of if, but when, a pandemic would happen. Exploring the panel’s unheeded recommendations can give the United States a blueprint for what to do going forward to protect us from the coronavirus and future threats. Hosted by Jim Greenwood. by I AM BIO
50 min listen
Coronavirus Lung Treatment Could be Ready In Weeks: Regeneron’s rheumatoid arthritis drug shows promise to treat coronavirus-related lung syndrome and stop the inflammation that leads to death. The company also expects to test a preventative antibody shot in June. Hosted by Jim Greenwood. by I AM BIO
40 min listen
Biotech’s Finest Hour: As the world waits for biotechnology to deliver COVID-19 treatments and a vaccine, Ambassador Deborah Birx tells BIO’s scientists: “Expectations are high because you’ve delivered for us before and I know that you can deliver for us again.” BIO chairman Jeremy Levin, a biotech pioneer, explains how the industry will rise to meet this moment. Hosted by Jim Greenwood. by I AM BIO
53 min listen
An Alternative to Flying Dirty: While Swedish climate activist Greta Thunberg has kindled a global dialogue about the ravages of climate change and the role of airline emissions, a Colorado biotech is putting forward a jaw-dropping alternative to flight shaming: actual jet fuel with no carbon footprint. Hosted by Jim Greenwood. by I AM BIO
40 min listen
Water Stress: Can We Avert a Looming Crisis?: More than two-thirds of the Earth’s surface is water, and yet water that is safe enough for human consumption remains a finite resource. In this episode we speak to experts about the biggest threats to water—contamination, overuse, and plastic. We also learn how innovative new tools can ensure there is enough water to hydrate us, our plants, and our animals. Guests: Ameen Razavi, Microvi Biotech Dr. Joel Cuello, The University of Arizona Scott Tuten, Danimer Scientific by I AM BIO
26 min listen
Hydroxychloroquine & the Shorting of Science: Patients with autoimmune diseases like lupus and rheumatoid arthritis have been forced to ration or skip doses of hydroxychloroquine during the pandemic due to shortages caused by off-label prescribing. Yet despite multiple FDA clinical studies that concluded the drug offers no clinical benefit against covid and may increase dangerous side effects; President Trump continues to use the bully pulpit to suggest otherwise. It's not like autoimmune patients — at greater risk of serious COVID disease, stress-induced flare-ups and vaccine complications — didn’t have enough to worry about already. by I AM BIO
31 min listen
Biotech's Finest Hour (Redux): As the world waits for biotechnology to deliver COVID-19 treatments and a vaccine, Ambassador Deborah Birx tells BIO’s scientists: “Expectations are high because you’ve delivered for us before and I know that you can deliver for us again.” BIO chairman Jeremy Levin, a biotech pioneer, explains how the industry will rise to meet this moment. Hosted by Jim Greenwood. by I AM BIO
48 min listen
First Dose: One day before 16-year-old Izzy Thorpe-Wall takes her first dose of Vertex’s stunning Cystic Fibrosis breakthrough, Thorpe and her mother, Clare, open up about their emotional journey and one brave girl’s determination to stay healthy long enough to meet this day of her dreams. Hosted by Jim Greenwood. by I AM BIO
43 min listen
Destroying COVID's Genome: Alnylam Pharmaceuticals, which take its name from the center and brightest star in Orion’s Belt, is working on an RNAi therapy to destroy the genome of the novel coronavirus — and with it, its ability to replicate and kill. Hosted by Jim Greenwood. by I AM BIO
39 min listen
The Other Pandemic: Beating “Nightmare Bugs” (Part 2 of 2): Viral pandemics can lead to secondary bacterial infections that kill millions, Dr. Anthony Fauci concluded after studying the 1918 Spanish flu. A century later, COVID and antibiotic resistance are proving to be a lethal combination. What are the biopharma industry and Congress doing to keep your loved ones safe from superbugs? Hosted by Jim Greenwood. by I AM BIO
32 min listen
Clinical Trials and Tribulations: As Moderna breaks the record for speed in starting the final stage of human testing for its covid vaccine, new BIO CEO Dr. Michelle McMurry-Heath tackles the thorny issue of how to best structure the historic Phase 3 clinical trial. The Boston biotech’s Chief Medical Officer reveals the strategy to test vaccine efficacy on communities of color and others hardest hit by the coronavirus. Hosted by Dr. Michelle McMurry-Heath by I AM BIO
29 min listen
Going Viral: Vir Biotechnology CEO George Scangos is the scientist selected by his peers to lead the biotechnology industry’s efforts to mitigate and ultimately end the pandemic. He explains how and why the novel coronavirus is so contagious and potentially dangerous to millions. Hosted by Jim Greenwood. by I AM BIO
23 min listen
Cancer in the COVID Era (Redux): Overcrowded hospitals during the pandemic can pose treatment challenges for patients with other serious illnesses. As Kite Pharma CEO Christi Shaw says, “Cancer doesn’t stop in a crisis.” Neither do her company’s employees, who go to extraordinary lengths to get personalized CAR-T treatments to patients around the world. Hosted by Jim Greenwood. by I AM BIO
20 min listen
Deep Diving for COVID Cures: By studying our earliest evolutionary ancestors in the ocean, marine biotech researchers are gaining fresh insights about everything from anti-virals to coronavirus nasal swab testing to the inner workings of our adaptive immune systems. Learn what sea sponges, lugworms and sharks can teach us about improving human health during this crisis. Hosted by Jim Greenwood. by I AM BIO
43 min listen
Bats Don’t Have Passports: Modernity is plowing new frontiers, bringing us closer to exotic wildlife rich in viruses that our immune systems have not evolved to fight. Preventing future pandemics will require global cooperation, local action and a comprehensive strategy to monitor infectious disease hotspots to reduce the risk of zoonotic disease. Hosted by Jim Greenwood. by I AM BIO
33 min listen
COVID-19’s True Origins: There's a joke among ecological health scientists that if “you don’t believe one person can change the world, try eating an undercooked bat.” However, what EcoHealth Alliance’s Dr. William Karesh — a world-renowned expert on zoonotic disease transmission — reveals about the trend line for animal-to-human viral transmission is no laughing matter. Hosted by Jim Greenwood. by I AM BIO
39 min listen
COVID-19 Could Generate 1st Computerized Vaccine: Futuristic biotech Moderna is the first to clinically test a coronavirus vaccine, created in weeks using only the virus’ genetic code. The company’s messenger RNA breakthrough may be just in time as a former CDC director warns that animal viruses spilling over to humans is the new normal. Hosted by Jim Greenwood. by I AM BIO
60 min listen
COVID X-FACTOR: The diversity of our adaptive immune system is why people are reacting so differently to the novel coronavirus. No two people present the virus the exact same way to their immune systems. We’ve evolved in this way as humans to ensure no virus can eradicate our species. Hosted by Jim Greenwood. by I AM BIO
32 min listen
Who Gets Vaccinated First?: As the vaccine race enters the homestretch, Pfizer and Moderna both announced that their mRNA vaccines was 95 percent effective in preventing COVID-19 during Phase 3 clinical trials. Emergency use authorization could be just weeks away. The National Academy of Sciences released an influential report about who gets vaccinated first while companies scale up vaccine production. The Academy makes a compelling case that prioritizing those with risky healthy conditions and risky, essential jobs is the surest way to mitigate death, serious disease, rising case counts and growing socioeconomic crises in vulnerable communities across the country. by I AM BIO
27 min listen
Bullish: Biotechnology investors, armed with troves of data and “misfit” minds, have become key-decision makers in everything from when to open up the states to which medicines can turn the tide in this pandemic the quickest. As the BIO Investor Forum kicks off virtually today, a biomedical renaissance has Wall Street bullish on biotech’s future. by I AM BIO
30 min listen
Vaccine Velocity: How can global nonprofits like the Center for Epidemic Preparedness Innovations (CEPI) deliver a safe and effective vaccine against the novel coronavirus in just 12 to 18 months when the world record for vaccine approval is four years? CEPI CEO Richard Hatchett, a 9/11 hero, says it’s all about smart planning. By the time governments give the green light on the safety and efficacy of a covid vaccine, manufacturer capacity will be pre-scaled up and able to quickly churn out doses by the tens or hundreds of millions. Hosted by Jim Greenwood. by I AM BIO
33 min listen
Good Trouble for Good Medicine: The COVID crisis has laid bare the inequities faced by certain populations in our health care system. It has become increasingly clear that the drug development process for a whole host of diseases often leaves these same populations behind through their absence or underrepresentation in clinical trials. This episode evaluates the problem and looks for ways to improve the process so that medicines and vaccines work for everyone who takes them. Hosted by Dr. Michelle McMurry-Heath with interviews from Gerren Wilson, Dr. Lisa Fitzpatrick, and RADM Richardae Araojo, Pharm.D., MS by I AM BIO
23 min listen
The Wrong Year to Skip Your Flu Shot: Two potentially deadly respiratory viruses — the coronavirus and the influenza virus — will test our health care system and American common sense this fall. As millions return to school, campus and work this fall, the 2020 flu season is shaping up to be something of a pandemic pressure test for our nation. Vaccinations, social distancing and mask-wearing will be the key to containing both flu and COVID and saving countless lives. Guest hosted by Phyllis Arthur. by I AM BIO
31 min listen

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Listener takeover: Your Biotech Questions Answered: YOU asked, and we answered. In this episode, we had our experts on standby to answer questions from you, our listeners. We discuss topics ranging from the safety of genetically modified foods (GMOs), to the new era of personalized medicine, feeding the world by 2050, and even what makes start-up companies attractive to investors. by I AM BIO
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Editing Cells Within the Body—a New CRISPR Frontier: With its potential to expand the horizons of what’s possible for patients, CRISPR is the new darling of biotech. Reaching an important milestone in 2023 with the FDA approval of a sickle cell treatment using CRISPR, the technology is poised to break new barriers for treating patients in the near future. In this episode we talk with two companies working together on the next generation of CRISPR: editing cells within the body. We discuss the progress and the challenge in making this breakthrough a reality. by I AM BIO
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What We Know About the Microbiome: The gut microbiome, which consists of trillions of bacteria, viruses, and fungi, plays a crucial role in our health. However, there is still much to learn about this complex ecosystem. On this episode we talk with experts who tell us where the science is—how much we know, and how much we don’t. Two companies, Bloom Science and Seres Therapeutics, are leveraging the microbiome to develop new therapeutics. The potential of the microbiome is vast, and further research and technological advancements will continue to unlock its benefits. by I AM BIO
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The Synbio Revolution is Here (REDUX): Innovative companies are using synthetic biology to engineer organisms and create new materials that could transform every sector of our economy, from health care to food and energy production. Those companies say we’ve entered a synbio revolution, and it holds potential to improve the health of people and our planet. In this episode, we talk with three synbio experts about how this convergence of genetic engineering, computer science and other scientific disciplines is making our world more sustainable. by I AM BIO
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28 min listen
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Matters Microbial #35: Clostridioides difficile: From Bench to Bedside and Back Again: Today, Dr. Vincent Young of the University of Michigan Department of Internal Medicine and Infectious Disease Division in Ann Arbor, joins the #QualityQuorum to chat about the ecology of the human gut as it relates to a serious bacterial disease... by Matters Microbial
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Episode 1: Bioprinting: Scientists have been printing cells for decades, but with the arrival of 3D bioprinters, getting printed tissue models to behave like living tissue has proved elusive. That is why angiogenesis and vascularization are two holy grails of 3D bioprinting. Al... by A view on
8 min listen
Science Helped Save the World from COVID. What will Vaccine Technology do Next?: 2021 was the unofficial year of mRNA—and deservedly so. But the science behind the technology is not always easy to understand. In this episode, we will dive into the miracle technology that saved countless lives and talk about what it holds for the future. We also speak to a biotech company about its non-mRNA vaccine technology for COVID and why the healthcare ecosystem will always need multiple options. by I AM BIO
25 min listen
481: Hijacker-Host Sequence Swap: This episode: Gene transfers between viruses and eukaryotes have happened many times throughout evolutionary history! (7.5 MB, 10.9 minutes) Show notes: Microbe of the episode: Mycoplasma subdolum Takeaways As we’ve all seen recently,... by BacterioFiles
11 min listen
Journal Club: Turning a Toxin into a Genome Editing Tool: In this episode of Journal Club we discuss the development of the first genome editing enzyme capable of performing precision edits to the mitochondrial genome. Mutations in the mitochondrial genome cause over 150 different human diseases, but none of our existing gene editing tools have been able to edit this DNA. This newly developed tool can be used to create better models of these diseases and and perhaps one day be used to treat them with gene therapy. by Raising Health
21 min listen
A New Technology Hiding in Covid Vaccines by Prognosis: Losing it
14 min listen
Directed Evolution of Antibodies with Doug Chapnick by Axial Podcast
54 min listen
Nick Conley – Chief Science Officer & Co-Founder of Epibiome – Combating Antibiotic Resistant Bacteria: EpiBiome, a microbiome engineering company based in San Francisco, is busy developing next generation antibacterials to fight a real problem; the growing threat of antibiotic resistant bacteria. Their focus is also… by Finding Genius Podcast
43 min listen
bit.bio: a new source of human cells: Synthetic biology company bit.bio opens its new Cambridge headquarters by Naked Scientists, In Short Special Editions Podcast
4 min listen
Kevin McKernan Talks COVID Vaccine DNA Contamination, the Monkey Virus SV40 Promoter, and What’s Actually in the Vaccines by American Thought Leaders
62 min listen
Shankar Balasubramanian on decoding DNA: The man who found a way to decode DNA at speed. by The Life Scientific
29 min listen

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Synbio Changes Everything

Synbio Changes Everything

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