The New Age of CRISPR (Redux)

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The New Age of CRISPR (Redux)

FromI AM BIO

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Length:

28 minutes

Released:

Jul 18, 2023

Format:

Podcast episode

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CRISPR has emerged as a powerful tool for altering DNA sequences with incredible precision, opening up new avenues of research into the treatment of disease. In this episode, we explore the science behind CRISPR, as well as its potential. From curing genetic disorders to creating new crop varieties, the possibilities seem endless. Our four guests today are scientists working to push these gene editing tools to the next frontier.

Released:

Jul 18, 2023

Format:

Podcast episode

Titles in the series (100)

Powerful stories of biotechnology breakthroughs, the people they help, and the global problems they solve. Hosted by BIO President & CEO Dr. Michelle McMurry-Heath.

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COVID-19 Could Generate 1st Computerized Vaccine: Futuristic biotech Moderna is the first to clinically test a coronavirus vaccine, created in weeks using only the virus’ genetic code. The company’s messenger RNA breakthrough may be just in time as a former CDC director warns that animal viruses spilling over to humans is the new normal. Hosted by Jim Greenwood. by I AM BIO
60 min listen
Going Viral: Vir Biotechnology CEO George Scangos is the scientist selected by his peers to lead the biotechnology industry’s efforts to mitigate and ultimately end the pandemic. He explains how and why the novel coronavirus is so contagious and potentially dangerous to millions. Hosted by Jim Greenwood. by I AM BIO
23 min listen
Bats Don’t Have Passports: Modernity is plowing new frontiers, bringing us closer to exotic wildlife rich in viruses that our immune systems have not evolved to fight. Preventing future pandemics will require global cooperation, local action and a comprehensive strategy to monitor infectious disease hotspots to reduce the risk of zoonotic disease. Hosted by Jim Greenwood. by I AM BIO
33 min listen
Vaccines are a Virtue: As biotech researchers work around the clock on a covid vaccine, ill-informed, anti-science anti-vaxxers must be denounced and excoriated in the public square. BIO’s head of infectious disease policy Phyllis Arthur administers a vital dose of vaccine education, because none of us is safe until we all are. Hosted by Jim Greenwood. by I AM BIO
33 min listen
COVID-19’s True Origins (Redux): There's a joke among ecological health scientists that if “you don’t believe one person can change the world, try eating an undercooked bat.” However, what EcoHealth Alliance’s Dr. William Karesh — a world-renowned expert on zoonotic disease transmission — reveals about the trend line for animal-to-human viral transmission is no laughing matter. Hosted by Jim Greenwood. by I AM BIO
39 min listen
The Antibody Test Shortage: Only antibody testing can tell us who has been infected and recovered from coronavirus and when it might be safe to return to work. There’s a massive global shortage of these tests, and a Maryland biotech is racing to bolster the U.S. supply. Hosted by Jim Greenwood. by I AM BIO
27 min listen
Superbuggin’: Incurable gonorrhea and the deadly hospital superbug C. diff offer a frightening window into the gathering public health menace of antibiotic resistance. If society doesn’t wake up and tackle the problem, we could be headed toward a calamity on the magnitude of climate change. Hosted by Jim Greenwood. by I AM BIO
28 min listen
Trying our Patients: As genetic sequencing gives scientists new tools to hone in on medical mysteries, Washington politicians flirt dangerously with policies that would stymie the genomic revolution while giving patients scant pricing relief at the pharmacy counter. Hosted by Jim Greenwood. by I AM BIO
36 min listen
Destroying COVID's Genome: Alnylam Pharmaceuticals, which take its name from the center and brightest star in Orion’s Belt, is working on an RNAi therapy to destroy the genome of the novel coronavirus — and with it, its ability to replicate and kill. Hosted by Jim Greenwood. by I AM BIO
39 min listen
Cancer in the COVID Era: Overcrowded hospitals during the pandemic can pose treatment challenges for patients with other serious illnesses. As Kite Pharma CEO Christi Shaw says, “Cancer doesn’t stop in a crisis.” Neither do her company’s employees, who go to extraordinary lengths to get personalized CAR-T treatments to patients around the world. Hosted by Jim Greenwood. by I AM BIO
20 min listen
An Alternative to Flying Dirty: While Swedish climate activist Greta Thunberg has kindled a global dialogue about the ravages of climate change and the role of airline emissions, a Colorado biotech is putting forward a jaw-dropping alternative to flight shaming: actual jet fuel with no carbon footprint. Hosted by Jim Greenwood. by I AM BIO
40 min listen
Biotech’s Finest Hour: As the world waits for biotechnology to deliver COVID-19 treatments and a vaccine, Ambassador Deborah Birx tells BIO’s scientists: “Expectations are high because you’ve delivered for us before and I know that you can deliver for us again.” BIO chairman Jeremy Levin, a biotech pioneer, explains how the industry will rise to meet this moment. Hosted by Jim Greenwood. by I AM BIO
53 min listen
Sickle Cell Saviors: Need a dose of inspiration in a time of national tragedy? A remarkable biotech breakthrough from Global Blood Therapeutics offers fresh hope to patients living with sickle-cell disease. Hosted by Jim Greenwood. by I AM BIO
62 min listen
COVID-19: We Were Warned: For years, leaders on the Bipartisan Commission on Biodefense told Congress and the White House that it wasn’t a matter of if, but when, a pandemic would happen. Exploring the panel’s unheeded recommendations can give the United States a blueprint for what to do going forward to protect us from the coronavirus and future threats. Hosted by Jim Greenwood. by I AM BIO
50 min listen
The Wrong Year to Skip Your Flu Shot: Two potentially deadly respiratory viruses — the coronavirus and the influenza virus — will test our health care system and American common sense this fall. As millions return to school, campus and work this fall, the 2020 flu season is shaping up to be something of a pandemic pressure test for our nation. Vaccinations, social distancing and mask-wearing will be the key to containing both flu and COVID and saving countless lives. Guest hosted by Phyllis Arthur. by I AM BIO
31 min listen
First Dose: One day before 16-year-old Izzy Thorpe-Wall takes her first dose of Vertex’s stunning Cystic Fibrosis breakthrough, Thorpe and her mother, Clare, open up about their emotional journey and one brave girl’s determination to stay healthy long enough to meet this day of her dreams. Hosted by Jim Greenwood. by I AM BIO
43 min listen
COVID-19’s True Origins: There's a joke among ecological health scientists that if “you don’t believe one person can change the world, try eating an undercooked bat.” However, what EcoHealth Alliance’s Dr. William Karesh — a world-renowned expert on zoonotic disease transmission — reveals about the trend line for animal-to-human viral transmission is no laughing matter. Hosted by Jim Greenwood. by I AM BIO
39 min listen
COVID X-FACTOR: The diversity of our adaptive immune system is why people are reacting so differently to the novel coronavirus. No two people present the virus the exact same way to their immune systems. We’ve evolved in this way as humans to ensure no virus can eradicate our species. Hosted by Jim Greenwood. by I AM BIO
32 min listen
The Greening of Medicine: As the pandemic lays bare the links between human and environmental health, neuroscience leader Biogen lays out the most aggressive fossil fuel elimination plan of any Fortune 500 company while doubling down on efforts to lead on clinical trial diversity and racial equity. by I AM BIO
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Coronavirus Lung Treatment Could be Ready In Weeks: Regeneron’s rheumatoid arthritis drug shows promise to treat coronavirus-related lung syndrome and stop the inflammation that leads to death. The company also expects to test a preventative antibody shot in June. Hosted by Jim Greenwood. by I AM BIO
40 min listen
“Herd” Immunity: Biotech companies are working feverishly to develop antibody therapies to provide short-term protection against COVID-19. But what if the novel coronavirus mutates and outwits traditional monoclonal antibodies? Well, that’s where the super cows come in. Hosted by Jim Greenwood. by I AM BIO
36 min listen
“Herd” Immunity (Redux): Biotech companies are working feverishly to develop antibody therapies to provide short-term protection against COVID-19. But what if the novel coronavirus mutates and outwits traditional monoclonal antibodies? Well, that’s where the super cows come in. Hosted by Jim Greenwood. by I AM BIO
36 min listen
COVID & the Plastics Problem: Fear and misinformation about how the coronavirus is transmitted has led to dangerous backsliding in society’s efforts to address plastic pollution. But we don’t have to lose this battle to win the COVID war. A Georgia biotech is first to market with a green biopolymer material that looks and feels like plastic but dissolves in ocean water. Hosted by Jim Greenwood. by I AM BIO
32 min listen
Vaccine Velocity: How can global nonprofits like the Center for Epidemic Preparedness Innovations (CEPI) deliver a safe and effective vaccine against the novel coronavirus in just 12 to 18 months when the world record for vaccine approval is four years? CEPI CEO Richard Hatchett, a 9/11 hero, says it’s all about smart planning. By the time governments give the green light on the safety and efficacy of a covid vaccine, manufacturer capacity will be pre-scaled up and able to quickly churn out doses by the tens or hundreds of millions. Hosted by Jim Greenwood. by I AM BIO
33 min listen
Respiratory Rescue?: The engine powering Maryland vaccine maker Novavax is a recombinant nanoparticle platform that is impressing vaccinologists as well as government and nonprofit funders. Learn about the innovative biotech generating big buzz in the global covid vaccine race. by I AM BIO
28 min listen
1st Alzheimer’s Prevention Trial: Thwarting the Brain’s Betrayal: The first clinical study dedicated to preventing Alzheimer’s disease is now in its late stages. The participants are 300 members of the same Colombian family with a rare gene mutation that gives them a 100 percent chance of developing Alzheimer’s disease. Armed with this new data, could neuroscientists be closing in on an elusive breakthrough to defeat neurodegeneration? by I AM BIO
30 min listen
Clinical Trials and Tribulations: As Moderna breaks the record for speed in starting the final stage of human testing for its covid vaccine, new BIO CEO Dr. Michelle McMurry-Heath tackles the thorny issue of how to best structure the historic Phase 3 clinical trial. The Boston biotech’s Chief Medical Officer reveals the strategy to test vaccine efficacy on communities of color and others hardest hit by the coronavirus. Hosted by Dr. Michelle McMurry-Heath by I AM BIO
29 min listen
Deep Diving for COVID Cures: By studying our earliest evolutionary ancestors in the ocean, marine biotech researchers are gaining fresh insights about everything from anti-virals to coronavirus nasal swab testing to the inner workings of our adaptive immune systems. Learn what sea sponges, lugworms and sharks can teach us about improving human health during this crisis. Hosted by Jim Greenwood. by I AM BIO
43 min listen
What Can Iceland Tell Us About COVID?: The people of Iceland — a country of 360,000 — eagerly volunteered for genetic research on how the coronavirus affects a homogeneous population. Amgen’s work in the Land of Fire and here at home could deliver answers and antibodies to help mitigate the pandemic threat. Hosted by Jim Greenwood. by I AM BIO
32 min listen
CDC Vaccine Chief: No Corners Cut: Dr. Nancy Messonnier leads the Centers for Disease Control and Prevention’s work to safely vaccinate the country. Whether the question is who to vaccine first, how to restore trust, or how to administer two doses of a vaccine stored at -70 degrees to a nation of 328 million people, she’s got the answers. by I AM BIO
24 min listen

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Editing Cells Within the Body—a New CRISPR Frontier: With its potential to expand the horizons of what’s possible for patients, CRISPR is the new darling of biotech. Reaching an important milestone in 2023 with the FDA approval of a sickle cell treatment using CRISPR, the technology is poised to break new barriers for treating patients in the near future. In this episode we talk with two companies working together on the next generation of CRISPR: editing cells within the body. We discuss the progress and the challenge in making this breakthrough a reality. by I AM BIO
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Is CRISPR the New Sickle Cell Savior?: 2023 ended with an exciting biotech breakthrough for sickle cell patients. A gene-editing therapy using the revolutionary CRISPR technology provides new hope and options for the nearly 100,000 Americans with sickle cell disease. In this episode, we talk with the company behind one of the life-changing therapies, CASGEVY, and speak with two advocates for sickle cell patients. by I AM BIO
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CODE BREAKER: Why Walter Isaacson Thinks CRISPR Will Change Life As We Know It by The Next Big Idea
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A Crack In Creation: The Power and Ethics of Gene Editing (Encore): The 2020 Nobel Prize in Chemistry was awarded to molecular microbiologists Jennifer Doudna and Emmanuelle Charpentier for their work on CRISPR, the revolutionary technology that gives scientists a way to accurately cut DNA and transform the genetic code of life. Likened to a pair of “genetic scissors,” CRISPR could open the door to cures for some cancers, sickle cell anemia, and other diseases. But it is not without controversy. It’s already been used to manipulate embryos. That could be the first step on the path to “designer babies,” and it raises a multitude of ethical questions. In this encore episode recorded in 2017, Doudna spoke with Walter Isaacson, then president of the Aspen Institute, about gene editing and what it could mean to have the power to control evolution. by Aspen Ideas to Go
59 min listen
George Calin, MD Discusses Promising Research on Small RNAs in Treating Cancers: Dr. George Calin holds M.D. and Ph.D. degrees from Carol Davila University of Medicine in Bucharest, Romania. He completed cancer genomics training at the University of Ferrara in Italy and was a post-doctor fellow at the Kimmel Center in... by Finding Genius Podcast
33 min listen
CRISPR | Making the world better: We sat down with Travis Hardcastle, a Product Manager for Engineered Cell Lines at Synthego, to talk all things CRISPR cell engineering. Here's a quick rundown of what we covered: • The basics of gene editing and how it's being applied to cell line engineering • How automation and bioproduction are being used in the CRISPR revolution • The potential of personalized medicine through this technology CRISPR Cas9 gene editing technology has come a long way since its discovery 10 years ago. It's no longer just a niche technique - it's mainstream and being used to tackle a wide range of challenges in applied biology. Don't miss out - give our first episode a listen and subscribe for future episodes. Share with any colleagues or friends who might be interested. Happy listening! - The Speaking of Mol Bio Team by Speaking of Mol Bio
30 min listen
On the Latest in Gene Editing and Genomic Research—Dr. Dana Carroll—Department of Biochemistry, University of Utah School of Medicine: Not more than 20 years ago, epigenetics was something not many people understood or even knew much about, but now we not only have a good understanding of epigenetics, but the ability to manipulate the epigenome. CRISPR is one of the new tools used in... by Finding Genius Podcast
40 min listen
#44 CRISPR: Listen to hear how CRISPR works and how it was discovered. Get the inside scoop on the current research, ethics, politics, and patents. by DNA Today: A Genetics Podcast
31 min listen
S4.08 Making better medicines: unlocking the promise of genomics for drug discovery: Unlocking the promise of genomics for drug discovery by Genetics Unzipped
40 min listen

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The New Age of CRISPR (Redux)

The New Age of CRISPR (Redux)

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