An interview with Jamie Heywood, who got into the medical research field when his brother was diagnosed with ALS and Jamie wanted to do everything he could do to save him. Jamie started an ALS research institute, and later was co-founder and CEO of PatientsLikeMe, an organization for collecting real-world medical data directly from patients. He discusses the strengths and challenges in collecting real-world patient-reported data, why such tactics haven't been as disruptive and revolutionary as their potential suggests, and thoughts on the problems we face in medical research and healthcare solutions in general.