Helium shortage 3.0 is winding down. But 2021 is likely to bring more changes to the global market for this critical, non-renewable gas. And even if there isn’t another crunch, scientists who use helium are tired of unstable supply of a material they need to keep their instruments running. In this episode of Stereo Chemistry, we’ll look at what’s behind the wobbly helium market and what scientists and instrument makers are doing to lift the heavy burden of helium use. A script for this episode is available at bit.ly/34nmunf. Find all of C&EN’s COVID-19 coverage at cenm.ag/coronavirus. Make a donation to support C&EN’s nonprofit science journalism at cenm.ag/donate. Image courtesy of Bruker BioSpin