As I promised in PART 1 of the Histamine Intolerance series, it’s time to talk about the connection of histamine to estrogen. Histamine and estrogen have a super messed up relationship that’s crucial to investigate in my clinical experience. They can go hand-in-hand with one fueling the other and so on, making your symptoms increasingly worse over time. Despite the deeper focus on estrogen, this episode is for both women AND men because both can end up victims of excess estrogen! And I’m going to share about the two enzymes that play an important role for breaking down histamine. Are you ready for this? Let’s dive in!!! In this episode: Genetic issues associated with DAO + HMNT enzymes Testing for SNPs that impact your histamine enzymes Estrogen-histamine relationship -- YIKES! What part of your menstrual cycle might you be MORE reactive to allergens? Quotes: You have genes that code for two very important enzymes that dictate histamine breakdown -- HMNT and DAO. There is research suggesting that estrogen could increase the number of histamine receptors making you even more sensitive to histamine.