Nels and Vincent review evidence that a single amino acid change in the SARS-CoV-2 spike protein has driven adaptation to humans, followed by an update on the status of variants of concern. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Selective sweep drove SARS-CoV-2 adaptation (bioRxiv) Novel coronavirus haplotypes Letters read on TWiEVO 65 Time stamps by Jolene. Thanks! Science Picks Nels – Radio Garden Vincent – Our World in Data – Coronavirus Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv