Nels and Vincent provide an update on cases of monkeypox, and summarize a biochemical view of three changes in the SARS-CoV-2 spike protein that may balance positive and negative selection. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiEVO Links for this episode ECDC monkeypox risk assessment (pdf) Monkeypox virus genomes (Nextstrain) Discussion of monkeypox virus genome sequencing (virological.org) Balancing positive and negative selection in spike protein (Biochem) Time stamps by Jolene. Thanks! Science Picks Nels – Science on the Side podcast by Morgan Nelson and Ty Chiaro  Vincent – Richard Ernst Lecture 2022 Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv