Senator Joe Manchin of West Virginia was always going to be the last Democrat to get on board with President Biden’s $2.2 trillion climate, social spending and tax bill. But the White House was confident that a compromise could be reached.On Sunday, that confidence was shattered: In an interview on Fox News, Mr. Manchin essentially declared that he could not support the bill as written, and he indicated that he was done negotiating all together.Where does this leave Mr. Biden’s signature domestic policy goal?Guest: Emily Cochrane, a correspondent for The New York Times, based in Washington.Sign up here to get The Daily in your inbox each morning. And for an exclusive look at how the biggest stories on our show come together, subscribe to our newsletter. Background reading: Mr. Manchin said on Sunday that he could not support the president’s signature bill, dooming his party’s drive to pass its marquee domestic policy legislation as written.Mr. Biden and his top aides have tried to salvage hopes of passing their domestic agenda, acknowledging that their only path forward is to repair a broken relationship with Mr. Manchin.For more information on today’s episode, visit nytimes.com/thedaily. Transcripts of each episode will be made available by the next workday.