In today's VETgirl online veterinary continuing education podcast, we review the use of telmisartan for the treatment of systemic hypertension in cats. Systemic hypertension (SH) in aged cats is predominantly due to chronic kidney disease (CKD), hyperthyroidism, or considered idiopathic. Downstream end-organ effects of chronic systemic hypertension target the eyes, myocardium, central nervous system, and kidneys (specifically, worsened renal function and proteinuria). Activation of the renin-angiotensin-aldosterone (RAAS) system contributes to development of SH in many cases and drugs that inhibit this system have treatment potential. Angiotensin II receptor blockers (ARBs) specifically block the angiotensin II, subtype-1 receptor (AT1) therefore inhibiting angiotensin II, which causes vasoconstriction, volume retention, sympathetic stimulation, inflammation, and fibrosis.