In this VetGirl podcast, we review baclofen toxicity, a centrally-acting muscle relaxant used commonly in human medicine. Unfortunately, ingestion by veterinary patients can cause significant morbidity and mortality. Clinical signs of baclofen toxicosis include severe dysphoria, agitation, profound sedation, bradycardia, hypoventilation, coma, and death. In this VetGirl podcast, we discuss common clinical signs when ingested by dogs and cats, treatment options, and prognosis.