Adrienne Randolph, MD, MSc, served as guest editor for the May 2005 supplement to Pediatric Critical Care Medicine. Dr. Randolph shares her thoughts on the importance of the 1st International Sepsis Forum on Sepsis in Infants and Children and the Pediatric Acute Lung Injury and Sepsis Investigator's (PALISI) Network. She also highlights the most important aspects from the supplement, which she played such an instrumental role in producing. (Pediatr Crit Care Med 2005 Vol. 6, No. 3 (Suppl.)