This audio program explores the role of ketamine and other NMDA antagonists as treatments for depression, and a replication study of a gene-environment interaction affecting depression risk. A study lasting four decades looked at whether ADHD in adults is a childhood-onset disorder, and another longitudinal study followed up adolescents at clinical high risk of psychosis, to see how many of them actually developed psychosis over the follow-up period. There also is discussion of a clinical trial of citicoline for cocaine dependence in bipolar I disorder. Articles may be viewed online at ajp.psychiatryonline.org.